SYNERGISTICALLY ACTING TERNARY ANTIMICROBIAL MIXTURES

• US 20130136709A1
• Filed: 11/05/2012
• Published: 05/30/2013
• Est. Priority Date: 11/04/2011
• Status: Active Grant

• Current Assignee: Symrise AG
• Original Assignee: Symrise AG
• Inventors: Pillai, Ravikumar, Schmaus, Gerhard, Khler, Antje
• Granted Patent: US 9,585,388 B2
• Time in Patent Office: Days
• US Class Current: 424/65
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A23L 3/3481 Organic compounds containing oxygen
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 2800/5922 At least two compounds being classified in the same subclass of A61K8/18
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/085 having an ether linkage to aromatic ring nuclear carbon
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 17/04 : Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 5/02 : Preparations for cleaning the hair

Abstract

The invention relates to synergistically effective ternary antimicrobial mixtures.

Claims

1. A mixture comprising:

(a) 2-phenoxyethanol, and

(b1+b2) at least two different alkanediol selected from the group consisting of 1,2-decanediol, 1,2-octanediol, 1,2-hexanediol, and 1,2-pentanediol.

2. A mixture according to claim 1, comprising:

(a) 2-phenoxyethanol,

(b1) 1,2-decanediol, and

(b2) 1,2-hexanediol and/or 1,2-pentanediol.

3. A mixture according to claim 1, wherein the weight ratio of component (a) to component (b1+b2) is 0.3-1.2 to 0.06-0.7.

4. A mixture according to claim 2, wherein the weight ratio of the components (a) to (b1) to (b2) is 0.3-1.2 to 0.05-0.4 to 0.01-0.3.

5. A mixture according to claim 1, wherein the weight ratio of the components (a) to (b1+b2) is adjusted in such a way that the antimicrobial action is synergistically intensified.

6. A cosmetic or pharmaceutical preparation or foodstuff comprising

an antimicrobially effective mixture according to claim 1, and

further usual ingredients.

7. A cosmetic or pharmaceutical preparation or foodstuff according to claim 6, wherein the total amount of components (a) and (b1+b2) is in the range from 0.01 to 10 wt %, relative to the total mass of the preparation or of the foodstuff.

8. A cosmetic or pharmaceutical preparation or foodstuff according to claim 6, comprising:

0.30 to 1.20 wt % of 2-phenoxyethanol,

0.05 to 0.40 wt % of 1,2-decanediol, and

0.01 to 0.30 wt % of the total amount of 1,2-hexanediol and/or 1,2-pentanediol,

in each case relative to the total mass of the preparation or of the foodstuff.

9. A cosmetic or pharmaceutical preparation or foodstuff according to claim 6, wherein the individual concentration of each of components (a), (b1) and (b2) is below the antimicrobially effective concentration, but the combined concentration of components (a), (b1) and (b2) is antimicrobially effective.

11. A method for the preservation or antimicrobial treatment of a perishable product comprising contacting the perishable product with an antimicrobially effective amount of a mixture according to claim 1.

12. A method for the:

(i) cosmetic treatment of microorganisms that cause body odour,

(ii) cosmetic treatment of microorganisms that cause acne,

(iii) cosmetic treatment of microorganisms that cause mycoses, and/or

(iv) treatment of microorganisms on or in inanimate matter,

comprising the application of an antimicrobially effective amount of a mixture according to claim 1 to the skin or on or in the inanimate matter.

13. A therapeutic method for treating:

(i) microorganisms that cause body odour,

(ii) microorganisms that cause acne and/or

(iii) microorganisms that cause mycoses,

comprising contacting the microorganisms with a mixture according to claim 1.

14. A mixture according to claim 2, wherein the weight ratios of the components (a) to (b1) to (b2) is adjusted in such a way that the antimicrobial action is synergistically intensified.

15. A cosmetic or pharmaceutical preparation or foodstuff according to claim 7, wherein the individual concentration of each of components (a), (b1) and (b2) is below the antimicrobially effective concentration, but the combined concentration of components (a), (b1) and (b2) is antimicrobially effective.

16. A method for the preservation or antimicrobial treatment of a perishable product comprising contacting the perishable product with an antimicrobially effective amount of a mixture according to claim 2.

17. A method for the preservation or antimicrobial treatment of a perishable product comprising contacting the perishable product with an antimicrobially effective amount of a mixture according to claim 3.

18. A method for the preservation or antimicrobial treatment of a perishable product comprising contacting the perishable product with an antimicrobially effective amount of a mixture according to claim 4.

19. A method for the preservation or antimicrobial treatment of a perishable product comprising contacting the perishable product with an antimicrobially effective amount of a mixture according to claim 5.

10. A method for synergistically intensifying the antimicrobial efficacy of at least two different alkanediols selected from the group consisting of 1,2-decanediol, 1,2-octanediol, 1,2-hexanediol, and 1,2-pentanediol comprising mixing a synergistically effective amount of 2-phenoxyethanol with the at least two different alkanediols.