MICROFABRICATED IMPLANTABLE WIRELESS PRESSURE SENSOR FOR USE IN BIOMEDICAL APPLICATIONS AND PRESSURE MEASUREMENT AND SENSOR IMPLANTATION METHODS

• US 20130137958A1
• Filed: 11/19/2012
• Published: 05/30/2013
• Est. Priority Date: 08/29/2006
• Status: Active Grant

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Tai, Yu-Chong, Chen, Po-Jui, Rodger, Damien C., Humayun, Mark S.
• Granted Patent: US 8,549,925 B2
• Time in Patent Office: Days
• US Class Current: 600/398
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence
• CPC Class Codes: G01L 9/0072 using variations in capacitance

Abstract

A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have a fixed or variable inductance. A variable capacitor and pressure sensors include a flexible member that is disposed on a substrate and defines a chamber. Capacitor elements extend indirectly from the flexible member. Sufficient fluidic pressure applied to an exterior surface of the flexible member causes the flexible member to move or deform, thus causing the capacitance and/or inductance to change. Resulting changes in resonant frequency or impedance can be detected to determine pressure, e.g., intraocular pressure.

Claims

1. (canceled)

2. A method of measuring intraocular pressure, comprising:

generating a signal with an external instrument;

energizing a pressure sensor implanted in an eye by the generated signal, the pressure sensor including an inductor and a variable capacitor having a flexible member and a plurality of capacitor elements extending indirectly from the flexible member and movable within respective channels defined within a substrate with changes of fluid pressure on the flexible member, capacitance varying with changes in an overlapping area of the plurality of capacitor elements and the substrate;

measuring an interaction between the signal generated by the external instrument and the pressure sensor; and

determining intraocular pressure based at least in part on the measured interaction.

3. The method of claim 2, wherein the flexible member is deformable from a relaxed shape to a deformed shape when fluid pressure on an outer surface of the flexible member exceeds an interior chamber pressure, thereby increasing the overlapping area and capacitance.

4. A method of measuring a fluid pressure, the method comprising:

deforming at least a portion of a flexible member on a substrate under the fluid pressure in order to vary an effective overlapping area between (i) variable capacitor electrodes associated with the flexible member, and (ii) a ground electrode associated with the substrate, thereby varying a capacitance thereacross; and

sensing the capacitance and determining the fluid pressure based at least in part thereon.

5. The method of claim 4, wherein the variable capacitor electrodes are movable within respective channels of the substrate.

6. The method of claim 4, wherein the variable capacitor electrodes extend indirectly from the flexible member.