Intravascular Tissue Disruption

• US 20130138082A1
• Filed: 01/23/2013
• Published: 05/30/2013
• Est. Priority Date: 03/24/2010
• Status: Abandoned Application

• Current Assignee: Shifamed Holdings, LLC
• Original Assignee: Shifamed Holdings, LLC
• Inventors: Salahieh, Amr, Saul, Tom, Kim, Eliot T., Ryan, Ari
• Application Number:
  US13/748,374
• Publication Number:
  US 20130138082A1
• Time in Patent Office: Days
• US Class Current: 604/509
• CPC Class Codes: A61B 17/3203 Fluid jet cutting instruments
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/0108 using radio-opaque or ultrasound markers
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 39/22 Valves or arrangement of valves A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405

Abstract

Medical systems and devices adapted to deliver a fluid agent to target tissue within a patient.

Claims

1. A method of delivering fluid into a patient, comprising:

maintaining a fluid agent under a substantially constant high pressure within a fluid reservoir;

opening a fluid control downstream of the fluid reservoir from a closed configuration to allow the fluid agent maintained at substantially constant high pressure to flow under high pressure from the fluid reservoir to a fluid aperture disposed downstream to the fluid control; and

delivering the fluid agent at high velocity out of the aperture and into the patient.

2. The method of claim 1 wherein opening the fluid control downstream the fluid reservoir comprises opening a fluid control that is disposed external to the patient.

3. The method of claim 1 further comprising positioning a delivery device comprising the aperture within a renal artery, and

wherein the delivering step comprises delivering the fluid agent at high velocity out of the aperture and into the patient such that the fluid agent interacts with nerves surrounding the renal artery and disrupts neural communication along the nerves to reduce hypertension.

4. The method of claim 1 wherein maintaining a fluid agent under substantially constant high pressure comprises maintaining a fluid agent at between 750 psi and 5000 psi.

5. The method of claim 1 further comprising positioning a delivery device comprising the aperture within a lumen, and positioning the aperture such that it faces radially outward from the longitudinal axis of the delivery device.

6. The method of claim 5 further comprising expanding an expandable member to position the aperture into engagement with the lumen wall.

7. The method of claim 6 wherein expanding the expandable member reconfigures a fluid delivery line secured to the expandable member.

8. The method of claim 1 further comprising closing the fluid control to thereby control the volume of the fluid agent that is delivered out of the fluid aperture.

9. The method of claim 1 wherein delivering the fluid agent at high velocity out of the aperture and into the patient comprises delivering the fluid agent at between 50 m/sec and 400 m/sec.

10. The method of claim 1 wherein the fluid agent flows out of the fluid reservoir at between about 5 mL/min and about 40 mL/min.

11. The method of claim 1 wherein delivering the fluid agent at high velocity out of the aperture and into the patient comprises delivering the fluid agent in a fluid pulse with a duration of between about 50 and 500 msec.

12. The method of claim 1 wherein delivering the fluid agent comprises delivering the fluid agent in a fluid pulse of between about 10 uL and about 500 uL of the fluid agent.

13. An apparatus for delivering fluid to a target location within a patient'"'"'s body, comprising:

a high pressure source adapted to maintain a fluid within a fluid reservoir at a substantially constant high pressure;

a fluid delivery device comprising a fluid delivery aperture, wherein the delivery device is adapted to be positioned within the patient; and

a fluid control disposed downstream the high pressure source and upstream the aperture, wherein the fluid control is configured to control the flow of fluid therethrough and to modify fluid communication between the fluid reservoir and the fluid delivery aperture.

14. The apparatus of claim 13 wherein the fluid control is a valve with an open configuration and a closed configuration.

15. The apparatus of claim 13 wherein the fluid control is adapted to be disposed external to the patient.

16. The apparatus of claim 13 further comprising an expandable member adapted to reposition the aperture against the lumen wall.

17. The apparatus of claim 13 wherein the fluid control is adapted to be activated from an off state to an on state and then back to the off state, with both on/off and off/on transitions less than about 15 msec.

18. The apparatus of claim 13 wherein the fluid delivery aperture has a diameter between about 1 mil and about 5 mils.

19. The apparatus of claim 13 wherein the high pressure fluid source is adapted to maintain a fluid agent under pressure between 750 psi and 5000 psi within the fluid reservoir.