Bone Regeneration Membrane and Method for Forming a Bone Regeneration Membrane
First Claim
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1. A bone regeneration membrane comprising:
- a dense layer made of resorbable polymer, said dense layer having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues,a nanofibrillar layer made of resorbable polymer and attached to the first surface of the dense layer, said nanofibrillar layer comprising fibers having a diameter of nanometer size, said fibers being interlaced so as to present an average pore size greater than 10 μ
m to allow cell permeability and bone tissue regeneration, the nanofibrillar layer having a permeability K between 0.4*10-9 m2 and 11*10-9 m2, preferably between 1*10-9 m2 and 4*10-9 m2, in particular substantially of 2*10-9 m2.
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Abstract
A bone regeneration membrane comprising:
- a dense layer made of resorbable polymer, said dense layer having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues,
- a nanofibrillar layer made of resorbable polymer and attached to the first surface of the dense layer, said nanofibrillar layer comprising fibers having a diameter of nanometer size, said fibers being interlaced so as to present an average pore size greater than 10 μm to allow cell permeability and bone tissue regeneration, the nanofibrillar layer having a permeability κ between 0.4*10-9 m2 and 11*10-9 m2, preferably between 1*10-9 m2 and 4*10-9 m2, in particular substantially of 2*10-9 m2.
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Citations
14 Claims
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1. A bone regeneration membrane comprising:
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a dense layer made of resorbable polymer, said dense layer having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues, a nanofibrillar layer made of resorbable polymer and attached to the first surface of the dense layer, said nanofibrillar layer comprising fibers having a diameter of nanometer size, said fibers being interlaced so as to present an average pore size greater than 10 μ
m to allow cell permeability and bone tissue regeneration, the nanofibrillar layer having a permeability K between 0.4*10-9 m2 and 11*10-9 m2, preferably between 1*10-9 m2 and 4*10-9 m2, in particular substantially of 2*10-9 m2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for forming a bone regeneration membrane, comprising the steps of:
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forming, at room temperature, a dense layer made of resorbable polymer, said dense layer having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues, forming, at room temperature, a nanofibrillar layer made of resorbable polymer, said nanofibrillar layer comprising fibers having a diameter of nanometer size, the step of forming the nanofibrillar layer comprising the steps of; mixing the resorbable polymer with a solvent to obtain a polymer solution, feeding a spray nozzle with said polymer solution, projecting said polymer solution through said nozzle with a gas jet adapted to pump the polymer solution by depression, wherein the projected resorbable polymer precipitates and solidifies by evaporation of the solvent to form the fibers interlaced so as to present an average pore size greater than 10 μ
m to allow cell permeability and bone tissue regeneration, the nanofibrillar layer having a permeability κ
between 0.4*10−
9 m2 and 11*10−
9 m2, preferably between 1*10−
9 m2 and 4*10−
9 m2, in particular substantially of 2*10−
9 m2,depositing the fibers on a collecting surface, attaching, at room temperature, said nanofibrillar layer to the first surface of the dense layer. - View Dependent Claims (10, 11, 12, 13, 14)
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Specification