System and Method for Guidance of Anesthesia, Analgesia and Amnesia
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Abstract
Method for determining anesthesia dosage includes following steps. First Interventional Agent (“FIA”) is administered to Patient at a first rate to achieve First Predetermined Plane of Anesthesia (“FPPA”). Brain waves of Patient are analyzed to formulate First Set of Data (“FSD”) corresponding to a self-norm during administration of FIA. First transfer function corresponding to patient biochemical reactions to FIA is computed from FSD. Rate of administration of FIA to Patient is altered by a selected amount after achievement of FPPA for first time required for Patient to deviate from FPPA by predetermined degree. An altered amount of FIA required to cause the predetermined deviation is determined as difference between amount of FIA that would have been delivered to Patient during first time at the first rate and an amount delivered to Patient during the first time at the altered rate. Patient is administered the altered amount of FIA.
10 Citations
50 Claims
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1-30. -30. (canceled)
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31. A method of determining a desired anesthesia dosage for a patient via a perturbation analysis, comprising:
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administering to the patient a first interventional agent at a first rate selected to achieve a first predetermined plane of anesthesia; analyzing brain waves of the patient to formulate a first set of data corresponding to a self-norm during administration of the first interventional agent; computing from the first set of data a first transfer function corresponding to patient biochemical reactions to the first interventional agent; altering the rate of administration of the first interventional agent to the patient by a selected amount after achievement of the first plane of anesthesia for a first time required for the patient to deviate from the first plane of anesthesia by a predetermined degree; determining an altered amount of the first interventional agent required to cause the predetermined deviation from the first plane of anesthesia as a difference between an amount of the first interventional agent that would have been delivered to the patient during the first time at the first rate and an amount delivered to the patient during the first time at the altered rate; and administering to the patient one of the altered amount of the first interventional agent and a portion of the altered amount of the first interventional agent. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method, comprising:
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administering to a patient a first interventional agent until the patient attains a desired plane of anesthesia; amplifying and digitizing brain waves of the patient before and after the administering step to generate a first set of digital data; amplifying and digitizing brain waves of the patient during a medical procedure to generate a second set of digital data; computing a first trajectory for a first index of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, using a microprocessor, the first index corresponding to a depth of anesthesia of the patient; determining, using the microprocessor, a recommended rate of delivery of the interventional agent to the patient as a function of the first trajectory, wherein the first interventional agent is one of an anesthetic, analgesic and amnesic agent; and outputting to a user the recommended rate of delivery of the first interventional agent. - View Dependent Claims (42, 43, 44, 45, 46, 47)
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48. A method of determining a desired anesthesia dosage for a patient comprising:
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administering to the patient a first interventional agent at a first rate selected to achieve a first plane of anesthesia; receiving data from the patient corresponding to the first plane of anesthesia of the patient; altering, after the patient has achieved the first plane of anesthesia, a rate of delivery of the first interventional agent to an altered rate for a first time required for the patient to deviate from the first plane of anesthesia by a predetermined degree; determining an altered amount of the first interventional agent required to cause the predetermined deviation from the first plane of anesthesia as a difference between an amount of the first interventional agent that would have been delivered to the patient during the first time at the first rate and an amount delivered to the patient during the first time at the altered rate; and administering to the patient one of the altered amount of the first interventional agent and a portion of the altered amount of the first interventional agent.
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- 49. The method of claim 49, wherein the data corresponds to brain waves of the patient.
Specification