MILK-BASED NUTRITIONAL COMPOSITIONS CONTAINING LACTOFERRIN AND USES THEREOF

• US 20130150306A1
• Filed: 12/18/2012
• Published: 06/13/2013
• Est. Priority Date: 12/29/2010
• Status: Active Grant

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Wittke, Anja
• Granted Patent: US 8,968,722 B2
• Time in Patent Office: Days
• US Class Current: 514/17.5
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/17 Amino acids, peptides or proteins
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/26 Polyol polyesters, e.g. sucrose polyesters; Synthetic sugar polymers, e.g. polydextrose
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61K 38/40 Transferrins, e.g. lactoferrins, ovotransferrins
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006

Abstract

The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.

Claims

1. A method for modulating psychological stress in a pediatric subject, the method comprising administering to the pediatric subject a milk-based nutritional composition comprising lactoferrin from a non-human source.

2. The method according to claim 1, wherein the lactoferrin is bovine lactoferrin.

3. The method according to claim 1, wherein the nutritional composition is an infant formula.

4. The method according to claim 1, wherein the nutritional composition additionally comprises about 3 g/100 kcal to about 7 g/100 kcal of fat source.

5. The method according to claim 1, wherein the nutritional composition additionally comprises about 1 g/100 kcal to about 5 g/100 kcal of a protein source.

6. The method according to claim 1, wherein the lactoferrin is present at a level of about 70 mg/100 kcal to about 220 mg/100 kcal.

7. The method according to claim 1, wherein the nutritional composition further comprises at least one prebiotic.

8. The method according to claim 7, wherein nutritional composition comprises about 0.1 g/100 kcal to about 1 g/100 kcal of the at least one prebiotic.

9. The method according to claim 7, wherein the at least one prebiotic comprises polydextrose.

10. The method according to claim 9, wherein the at least one prebiotic further comprises galactooligosaccharide.

11. The method according to claim 9, wherein polydextrose comprises at least about 20% w/w of the at least one prebiotic.

12. A method for modulating plasma corticosterone levels in a pediatric subject, the method comprising administering to the pediatric subject a milk-based nutritional composition comprising bovine lactoferrin.

13. The method according to claim 12, wherein the nutritional composition further comprises at least one prebiotic.

14. The method according to claim 13, wherein the at least one prebiotic is present at a level of about 0.1 g/100 kcal to about 1 g/100 kcal.

15. The method according to claim 13, wherein the at least one prebiotic comprises polydextrose.

16. The method according to claim 15, wherein the at least one prebiotic further comprises galactooligosaccharide.

17. The method according to claim 15, wherein polydextrose comprises at least about 20% w/w of the at least one prebiotic.

18. A method for supporting gastrointestinal development in a pediatric subject, the method comprising administering to the pediatric subject a milk-based nutritional composition comprising bovine lactoferrin and a prebiotic component comprising polydextrose.

19. The method according to claim 18, wherein polydextrose comprises at least 20% w/w of the prebiotic component.

20. The method according to claim 18, wherein the prebiotic component further comprises galactooligosaccharide.