METHODS AND SYSTEMS FOR IDENTIFYING AND USING HEART RATE VARIABILITY AND HEART RATE VARIATION

• US 20130150911A1
• Filed: 12/06/2012
• Published: 06/13/2013
• Est. Priority Date: 12/12/2011
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Perschbacher, David L., Sharma, Arjun D., Stolen, Craig, Stolen, Kira Q., Seth, Milan, Jones, Paul W.
• Granted Patent: US 8,983,603 B2
• Time in Patent Office: Days
• US Class Current: 607/18
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/36535 controlled by body position or posture
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability

Abstract

A heart rate variability or heart rate variation can be identified using sensed and/or paced heart beats. One or more patient metrics, such as a variability index or a variation index, can correspond to the identified heart rate variability or heart rate variation. The patient metrics can be used to identify a need for a particular therapy, such as a rate-responsive pacing therapy. The patient metrics can be used to identify patients at an elevated risk of death. Methods and systems to identify therapy indications or at-risk patients are provided. In an example, a patient risk profile can be adjusted, such as in response to an identified patient heart rate variability or heart rate variation. In an example, a rate-responsive pacing mode can be used to adjust the patient risk profile.

Claims

1. An apparatus comprising:

a data input circuit configured to receive information indicative of a patient heart rate including information about both intrinsic and non-intrinsic patient heart beats;

a memory circuit configured to store information about the patient heart rate over time; and

a processor circuit, coupled to the memory circuit, the processor circuit configured to;

determine a heart rate variation using the stored information about the patient heart rate over time, the determined heart rate variation indicative of a number of both intrinsic and non-intrinsic patient heart beats within a specified heart rate range; and

compute a patient metric using the determined heart rate variation indicative of a number of both the intrinsic and non-intrinsic patient heart beats within the specified heart rate range.

2. The apparatus of claim 1, wherein the processor circuit is configured to determine a rate-responsive pacing mode suitability indication for the patient using the computed patient metric.

3. The apparatus of claim 2, wherein the processor circuit is configured to identify a lesser suitability for the rate-responsive pacing mode for the patient when the heart rate variation is at a first heart rate variation value, and identify a greater suitability for the rate-responsive pacing mode for the patient when the heart rate variation is at a second heart rate variation value that is less than the first heart rate variation value.

4. The apparatus of claim 2, wherein the processor circuit is configured to determine whether a count of the patient'"'"'s non-intrinsic heart beats exceeds a specified portion of a total count of the patient'"'"'s intrinsic and non-intrinsic heart beats during a specified period, and, when the count of the patient'"'"'s non-intrinsic heart beats exceeds the specified portion of the total count of the patient'"'"'s intrinsic and non-intrinsic heart beats during the specified period, determine the rate-responsive pacing mode suitability indication for the patient.

5. The apparatus of claim 2, comprising a physiologic sensor configured to provide a signal indicative of the patient'"'"'s metabolic need for a particular level of cardiac output, wherein the rate-responsive pacing mode is capable of automatically adjusting a patient pacing rate as a function of a variation in the signal indicative of the patient'"'"'s metabolic need for the particular level of cardiac output.

6. The apparatus of claim 5, wherein the physiologic sensor configured to provide the signal indicative of the patient'"'"'s metabolic need comprises an impedance sensor configured to provide a signal indicative of the patient'"'"'s respiration status and/or an accelerometer configured to provide a signal indicative of the patient'"'"'s physical activity level.

7. The apparatus of claim 1, wherein the memory circuit is configured to store the information about the patient heart rate in a heart rate histogram bin corresponding to a patient heart rate range;

and

wherein the processor circuit is configured to determine the heart rate variation using information about the heart rate histogram.

8. The apparatus of claim 7, wherein the processor circuit is configured to determine the heart rate variation using a morphology characteristic of the heart rate histogram.

9. The apparatus of claim 1, wherein the processor circuit is configured to compute, as the patient metric, a predictive patient mortality indication using the determined heart rate variation.

10. The apparatus of claim 9, wherein the processor circuit is configured to identify a lesser patient mortality rate for the patient when the heart rate variation is at a first heart rate variation value, and identify a greater patient mortality rate for the patient when the heart rate variation is at a second heart rate variation value that is less than the first heart rate variation value.

11. The apparatus of claim 1, wherein the data input circuit is configured to receive a cardiac activity signal that includes information about atrial contractions of the patient'"'"'s heart;

and

wherein the processor circuit is configured to determine the heart rate variation using the received cardiac activity signal that includes information about atrial contractions.

12. The apparatus of claim 1, wherein the processor circuit is configured to adjust a patient therapy using the computed patient metric.

13. The apparatus of claim 1, wherein the processor circuit is configured to initiate or adjust a rate-responsive pacing mode in a pacemaker in response to the determined heart rate variation.

14. The apparatus of claim 1, wherein the processor circuit is configured to adjust, in response to the determined heart rate variation, at least one of:

a maximum pacing rate that controls a maximum rate at which a pacemaker supplies pacing energy to a heart;

a lower rate limit that controls at which heart rate a pacemaker begins to supply pacing energy to a heart;

a patient exertion level threshold that controls at which patient physical activity level a pacing energy is initiated or adjusted;

a rate-response reaction time that controls how quickly a pacing rate increases;

a rate-response response factor that controls a pacing rate as a function of a patient exertion level;

or

a rate-response recovery time that controls a rate at which a pacing rate decreases from a maximum pacing rate to a lower rate limit when a patient exertion level is less than a specified threshold physical activity level.

15. The apparatus of claim 1, comprising a patient posture sensor, wherein the processor circuit is configured to adjust the computed patient metric using the determined heart rate variation and information received from the patient posture sensor.

16. The apparatus of claim 1, wherein the processor circuit is configured to automatically provide a recommendation for a cardiac rhythm management device using the determined heart rate variation.

17. A method comprising:

obtaining patient heart rate information including information about both intrinsic and non-intrinsic patient heart beats;

determining a heart rate variation using the patient heart rate information including information about both intrinsic and non-intrinsic patient heart beats, the heart rate variation indicative of a number of both intrinsic and non-intrinsic patient heart beats within a specified heart rate range; and

computing a patient metric using the determined heart rate variation indicative of a number of both intrinsic and non-intrinsic patient heart beats within a specified heart rate range.

18. The method of claim 17, comprising determining a rate-responsive pacing mode suitability indication for the patient, the rate responsive pacing mode capable of automatically adjusting a pacing rate in response to a variation in a physiologic sensor output indicating a variation in the patient'"'"'s metabolic need for a particular level of cardiac output.

19. The method of claim 17, comprising providing a predictive patient mortality indication using the determined heart rate variation.

20. An apparatus comprising:

a data input circuit configured to receive information indicative of a patient heart rate including information about both intrinsic and non-intrinsic patient heart beats;

a memory circuit configured to store information about the patient heart rate over time; and

a processor circuit, coupled to the memory circuit, the processor circuit configured to;

determine a heart rate variation using the stored information about the patient heart rate over time, the determined heart rate variation indicative of a number of both intrinsic and non-intrinsic patient heart beats within a specified heart rate range; and

compute a predictive patient mortality indication using the determined heart rate variation, including identifying a lesser patient mortality rate for the patient when the heart rate variation is at a first heart rate variation value, and identifying a greater patient mortality rate for the patient when the heart rate variation is at a second heart rate variation value that is less than the first heart rate variation value.