SCAFFOLD SYSTEM TO REPAIR CARDIOVASCULAR CONDITIONS
First Claim
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1. A device for treating a cardiovascular condition comprising:
- an expandable scaffold supported by stent technology, wherein the scaffold is comprised of nonwoven fibers electrospun from a biomaterial compound, and wherein the scaffold is substantially tubular and comprises a concave surface having an higher concentration of fibers than the convex surface,wherein, when the scaffold is positioned in the vasculature of a mammal to direct tissue development and control blood flow into the undesirable cardiovascular condition, the concave surface of the scaffold inhibits blood flow while providing an appropriate surface for cell attachment while the less concentrated convex surface facilitates the ingress and organization of cells.
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Abstract
A device for treating a cardiovascular condition includes an expandable scaffold positionable in a portion of a vasculature of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The biodegradable compound serves as a temporary template that allows the cardiovascular tissue to be rebuilt about the scaffold.
27 Citations
22 Claims
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1. A device for treating a cardiovascular condition comprising:
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an expandable scaffold supported by stent technology, wherein the scaffold is comprised of nonwoven fibers electrospun from a biomaterial compound, and wherein the scaffold is substantially tubular and comprises a concave surface having an higher concentration of fibers than the convex surface, wherein, when the scaffold is positioned in the vasculature of a mammal to direct tissue development and control blood flow into the undesirable cardiovascular condition, the concave surface of the scaffold inhibits blood flow while providing an appropriate surface for cell attachment while the less concentrated convex surface facilitates the ingress and organization of cells. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10)
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2-3. -3. (canceled)
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11. A method of treating a cardiovascular condition comprising:
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inserting a device into the vasculature of a mammal;
the device comprising;an expandable scaffold supported by stent technology, wherein the scaffold is comprised of nonwoven fibers electrospun from a biomaterial compound, and wherein the scaffold is substantially tubular and comprises a concave surface having an higher concentration of fibers than the convex surface, wherein, when the scaffold is positioned in the vasculature of a mammal to direct tissue development and control blood flow into the undesirable cardiovascular condition, the concave surface of the scaffold inhibits blood flow while providing an appropriate surface for cell attachment while the less concentrated convex surface facilitates the ingress and organization of cells; and securing the device in the vasculature. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
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12-13. -13. (canceled)
Specification