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METHODS FOR MULTIPLEXED SELECTION OF FUNCTIONAL LIGANDS

  • US 20130157871A1
  • Filed: 10/15/2012
  • Published: 06/20/2013
  • Est. Priority Date: 03/23/2009
  • Status: Abandoned Application
First Claim
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1. A method of selecting aptamers comprising:

  • contacting a plurality of identifiers each of which comprising an oligonucleotide comprising a unique identity sequence denoting a predetermined position on a substrate with a corresponding plurality of target spots disposed at predetermined positions on said substrate, wherein each of said target spots comprising at least one potential aptamer bound to at least one target molecule; and

    attaching any of said plurality of identifiers to any of said at least one aptamers bound at one of said target spots by hybridizing, each of said oligonucleotides comprising a first constant region which hybridizes to a second constant region on each of said aptamers;

    wherein each of said unique identity sequences of said plurality of identifiers correlate to one of said predetermined positions on said substrate.

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