Moisturizing Composition Comprising an Aminopeptide Mixture

• US 20130157957A1
• Filed: 11/29/2012
• Published: 06/20/2013
• Est. Priority Date: 12/20/2011
• Status: Active Grant

• Current Assignee: Conopco (Unilever PLC)
• Original Assignee: Conopco (Unilever PLC)
• Inventors: Pashkovski, Eugene, Litvin, Tamara, Lips, Alexander
• Granted Patent: US 8,815,800 B2
• Time in Patent Office: Days
• US Class Current: 514/18.8
• CPC Class Codes: A61K 2800/5922 At least two compounds being classified in the same subclass of A61K8/18
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/442 substituted by amido group(s)
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/673 Vitamin B group
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin

Abstract

The invention is directed to skin moisturizing compositions comprising an aminopeptide mixture. The composition replenishes the skins natural moisturization factor and delivers excellent sensory benefits. The composition is not unpleasantly viscous during and after application.

Claims

1. A skin composition comprising:

a) an aminopeptide mixture comprising;

i. a water soluble amino acid or functionalized amino acid;

ii. water soluble dipeptide having a molecular weight from about 150 to about 410;

iii. water soluble tripeptide having a molecular weight from about 225 to about 600 or water soluble vitamins comprising peptide bonds or both; and

b) cosmetically acceptable carrier

wherein amino acid and water soluble dipeptide together make up from 50 to 99% by weight of the total weight of the aminopeptide mixture.

2. The skin composition according to claim 1 wherein the amino acid or functionalized amino acid has a partitioning coefficient log kp of −

4.5 to 0 in n-octanol-water.

3. The skin composition according to claim 1 wherein the amino acid or functionalized amino acid is selected from the group consisting of glutamine, aspargine, glycine, glutamic acid, threonine, lysine, alanine, serine, hydroxyproline, N-acetyl-L-tyrosine, N-acetyl-L-hydroxyproline, N-acetyl-L-cysteine, L-ornitine monochloride and a mixture thereof.

4. The skin composition according to claim 1 wherein the dipeptide is glycyl-L-glytamine, glycyl-L-tyrosine, L-alanyl-L-glytamine, glycylglycine, lysyl lysine, glycyl alanine, glycyl lysine, glycyl hystidine or a mixture thereof.

5. The skin composition according to claim 1 wherein the water soluble vitamin comprising peptide bond comprises D-L-panthenol and the water soluble vitamin derivative comprises calcium pantetheine-S-sulfonate.

6. The skin composition according to claim 1 wherein the tripeptide is L-glytathione, S-methylglutathione, glycl-prolyl-glutaminc acid, lysyl-tyrosyl-lysine, lysyl-tyrosyl-lysine, glycyl-glycyl-histidine lysyl-lysyl-lysine or a mixture thereof.

7. The skin composition according to claim 1 wherein total weight of amino acid and dipeptide in the aminopeptide mixture is from about 50 to 80%.

8. The skin composition according to claim 1 wherein amino acid makes up from about 5 to about 50% by weight of the aminopeptide mixture.

9. The skin composition according to claim 1 wherein the aminopeptide mixture has a glass transition temperature from about −

75 to about 15°

C.

10. The skin composition according to claim 1 wherein the aminopeptide mixture has a glass transition temperature from about −

48 to about 12°

C.

11. The skin composition according to claim 1 wherein the composition further comprises niacinamide.

12. The skin composition according to claim 1 wherein the composition further comprises a cationic ammonium compound, substituted urea, glycerol or a mixture thereof.

13. The skin composition according to claim 1 wherein the composition further comprises sunscreen, a resorcinol or a mixture thereof.

14. The skin composition according to claim 1 wherein the composition is capable of replenishing skin natural moisturization factor.

15. The skin composition according to claim 1 wherein the composition further comprises water, silicone and emulsifier.

16. A method for moisturizing skin by replenishing natural moisturization factor of skin, the method comprising the step of topically applying to skin the composition of claim 1.