SUSTAINED DRUG RELEASE AND IMPROVED PRODUCT STABILITY USING NON-COVALENT PARTICLE COATING METHODS
First Claim
1. A method comprising the following steps:
- (a) dissolving an active agent or drug in a solvent to form a solution containing the active agent or drug; and
(b) evaporating the solvent from the solution until a substrate powder is formed, the substrate powder comprising the active agent or drug non-covalently bound to a substrate, wherein the substrate is a polymer or crystalline excipient.
2 Assignments
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Accused Products
Abstract
The present invention relates to improved methods of making compositions and compositions made by these methods having improved stability and/or extended release of an active agent or drug upon administration. These compositions may generally comprise an active agent or drug non-covalently immobilized or bound to an excipient substrate. The active agent or drug may include a wide variety of drugs. Binding of the active agent or drug to the substrate may be achieved by evaporating a solvent containing the active agent dissolved therein or by triggering co-precipitation by addition of a precipitating solvent. Additional steps of vacuum removal of surrounding atmosphere and replacement with inert gas may provide additional stability. Present methods and compositions also facilitate manufacturing of drug products and may make these processes safer in some cases. The present invention further provides improved methods of treatment or administration, which may take advantage of improvements with present compositions.
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Citations
67 Claims
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1. A method comprising the following steps:
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(a) dissolving an active agent or drug in a solvent to form a solution containing the active agent or drug; and (b) evaporating the solvent from the solution until a substrate powder is formed, the substrate powder comprising the active agent or drug non-covalently bound to a substrate, wherein the substrate is a polymer or crystalline excipient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 52, 53, 54)
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48. A method comprising the following steps:
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(a) dissolving an active agent or drug in a dispersing solvent to form a solution containing the active agent or drug; (b) co-precipitating the active agent or drug and a substrate by adding a precipitating solvent to the solution to form a precipitate, the precipitate comprising the active agent or drug non-covalently bound to the substrate, wherein the substrate is a polymer or crystalline excipient. - View Dependent Claims (49, 50, 51)
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55. A method comprising the following steps:
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administering a pharmaceutical composition to an individual, the pharmaceutical composition comprising a substrate powder, wherein the substrate powder comprises an active agent or drug non-covalently bound to a substrate, the substrate being a polymer or crystalline excipient. - View Dependent Claims (56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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Specification