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Humanized Light Chain Mice

  • US 20130160153A1
  • Filed: 12/17/2012
  • Published: 06/20/2013
  • Est. Priority Date: 12/20/2011
  • Status: Active Grant
First Claim
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1. A non-human animal comprising(a) an insertion of one or more human Vλ

  • and Jλ

    gene segments upstream of an non-human immunoglobulin light chain constant region,(b) an insertion of one or more human VH, one or more human DH and one or more human JH gene segments upstream of an non-human immunoglobulin heavy chain constant region, and(c) a nucleotide sequence that encodes an ADAM6 protein or a functional fragment thereof, wherein the ADAM6 protein is expressed from an ectopic ADAM6 nucleic acid sequence.

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