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GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES

  • US 20130167256A1
  • Filed: 03/31/2011
  • Published: 06/27/2013
  • Est. Priority Date: 03/31/2010
  • Status: Active Grant
First Claim
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1. A method of producing a cell comprising a genome that comprises a chimeric immunoglobulin chain, wherein said immunoglobulin chain comprises a non-endogenous variable domain and a chimeric constant region, said method comprising the steps of:

  • designing a DNA construct in silico, wherein said construct comprises one or more non-endogenous V, (D) and/or J gene segments and one or more non-endogenous constant region gene segments;

    producing said DNA construct; and

    introducing the construct into the genome of a cell.

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