ION-BASED BREATH ANALYSIS SYSTEM
First Claim
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1. A breath analysis system, comprising:
- a breath sample preparation system, comprising;
a first inlet configured to receive a patient'"'"'s expired breath comprising an analyte of interest;
a second inlet configured to receive a carrier gas; and
a mixing chamber configured to mix at least a portion of the patient'"'"'s expired breath with the carrier gas to generate a gas mixture; and
an ion detection system operatively coupled to the preparation system, comprising;
a gas path configured to flow the gas mixture;
an ionization source disposed along the gas path and configured to ionize at least the analyte of interest within the gas mixture; and
an ion detector disposed along the gas path downstream from the ionization source and configured to detect the ionized analyte of interest.
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Abstract
Disclosed embodiments include systems for analyzing the breath of a patient for the presence of one or more analytes of interest. The systems may include an ion detection system capable of receiving a gas mixture having an analyte of interest expired by a patient, flowing the gas mixture, and ionizing molecules within the gas mixture. The molecules include at least the analyte of interest. The ion detection system is also capable of detecting the ionized analyte of interest.
25 Citations
26 Claims
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1. A breath analysis system, comprising:
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a breath sample preparation system, comprising; a first inlet configured to receive a patient'"'"'s expired breath comprising an analyte of interest; a second inlet configured to receive a carrier gas; and a mixing chamber configured to mix at least a portion of the patient'"'"'s expired breath with the carrier gas to generate a gas mixture; and an ion detection system operatively coupled to the preparation system, comprising; a gas path configured to flow the gas mixture; an ionization source disposed along the gas path and configured to ionize at least the analyte of interest within the gas mixture; and an ion detector disposed along the gas path downstream from the ionization source and configured to detect the ionized analyte of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A breath analysis system, comprising:
an ion detection system, comprising; an inlet configured to receive a gas mixture having an analyte of interest expired by a patient; a gas path configured to flow the gas mixture; an ionization source disposed along the gas path and configured to ionize molecules within the gas mixture, the molecules comprising at least the analyte of interest; and an ion detector disposed along the gas path downstream from the ionization source and configured to detect the ionized analyte of interest. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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23. A breath analysis system, comprising:
an ion detection system, comprising; a substrate comprising one or more thru holes configured to enable the breath analysis system to integrate onto a circuit board, wherein the substrate comprises; an inlet configured to receive a gas mixture having an analyte of interest from a patient'"'"'s expired breath; and a gas path fluidly coupled to the inlet and formed within the substrate, wherein the gas path is configured to flow the gas mixture within the substrate toward an outlet of the substrate; an ionization source coupled to the substrate and disposed along the gas path, wherein the ionization source is configured to ionize at least the analyte of interest within the gas mixture; an ion filter coupled to an inner surface of the substrate along the gas path and configured to separate the ionized analyte of interest from other components of the gas mixture; and an ion detector coupled to the inner surface of the substrate along the gas path and downstream from the ion filter, wherein the ion detector is configured to generate a signal in response to detecting the presence of the ionized analyte of interest. - View Dependent Claims (24, 25, 26)
Specification