ANALYTE SENSOR WITH EXTENDED RANGE OF DETECTION
First Claim
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1. An analyte sensor, comprising:
- a base having an upper surface and an opposite lower surface, a first end, and an opposite second end; and
a first and a second analysis region coupled to the base, the first analysis region comprising a first analyte reagent system and the second analysis region comprising a second analyte reagent system,wherein the first and the second analysis regions have contiguous first and second detection ranges, respectively, for a target analyte, and substantially coextensive ranges of response, the first and second analysis regions configured to exhibit different responses within said coextensive ranges upon exposure to a given concentration of the target analyte.
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Abstract
Embodiments provide sensors, such as implantable sensors, and methods of producing such sensors. An implantable sensor may include a base, one or more chambers, and one or more sensor reagents. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be at least partially implanted into the dermis of an animal. One or more of the sensor reagents may emit light or exhibit a color change in response to the presence of a target analyte or reaction product thereof. The response may be detected and analyzed by the user or by a reader device to determine the target analyte concentration.
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Citations
72 Claims
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1. An analyte sensor, comprising:
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a base having an upper surface and an opposite lower surface, a first end, and an opposite second end; and a first and a second analysis region coupled to the base, the first analysis region comprising a first analyte reagent system and the second analysis region comprising a second analyte reagent system, wherein the first and the second analysis regions have contiguous first and second detection ranges, respectively, for a target analyte, and substantially coextensive ranges of response, the first and second analysis regions configured to exhibit different responses within said coextensive ranges upon exposure to a given concentration of the target analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. An analyte detection system for monitoring the concentration of a target analyte in the dermis of a subject, the system comprising:
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an implantable analyte sensor with a first analysis region and a second analysis region, the first and second analysis regions having contiguous first and second detection ranges for a target analyte, respectively, and substantially coextensive ranges of response; and a reader device having an optical sensor, a processor, and a non-volatile computer-readable storage medium endowed with instructions operable, upon execution by the processor, to cause the reader device to capture an image of the analyte sensor within the dermis of the subject, and calculate the concentration of the target analyte based at least on the captured image. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A reader device for use with an analyte sensor implanted into the dermis of a subject, wherein the analyte sensor includes a plurality of analysis regions with contiguous detection ranges for a target analyte and coextensive ranges of response, the reader device comprising:
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an optical sensor; a processor; and a non-volatile computer-readable storage medium endowed with instructions operable, upon execution by the processor, to cause the reader device to detect responses exhibited by two or more of the analysis regions to the target analyte, determine corresponding detection ranges of the two or more analysis regions, and calculate, based at least on the detected responses and the corresponding detection ranges, a concentration of the target analyte in the subject. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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65. A method of monitoring a concentration of a target analyte in the dermis of a subject, the method comprising:
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positioning an analyte sensor at least partially within the dermis of the subject, wherein the analyte sensor includes two or more analysis regions configured to detect a target analyte within different concentration ranges, and wherein the two or more analysis regions have contiguous detection ranges and coextensive ranges of response; detecting, by a reader device positioned above the dermis, responses exhibited by the two or more analysis regions; and calculating, based at least on the detected responses, the concentration of the target analyte, wherein the reader device is a mobile electronic device selected from the group consisting of a laptop, a tablet PC, or a mobile phone. - View Dependent Claims (66, 67, 68, 69, 70, 71)
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72. The method of claim 77, wherein calculating the concentration of the target analyte includes calculating a representative value for each of the selected areas further comprises averaging at least some of the calculated representative values.
Specification