METHODS OF TREATING DISEASES WHICH ARE MEDIATED BY CUTANEOUS LYMPHOCYTE ANTIGEN POSITIVE CELLS

• US 20130177563A1
• Filed: 01/30/2013
• Published: 07/11/2013
• Est. Priority Date: 02/14/2005
• Status: Abandoned Application

• Current Assignee: Zymogenetics Incorporated (Bristol-Myers Squibb Company), National Jewish Medical and Research Center
• Original Assignee: Zymogenetics Incorporated (Bristol-Myers Squibb Company), National Jewish Medical and Research Center
• Inventors: GROSS, JANE A., LEUNG, DONALD Y.M., BILSBOROUGH, JANINE M.
• Application Number:
  US13/754,278
• Publication Number:
  US 20130177563A1
• Time in Patent Office: Days
• US Class Current: 424/135.1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/545 characterised by the dose, timing or administration schedule
• CPC Class Codes: A61K 39/3955 against proteinaceous materials, e.g. enzymes, hormones, lymphokines
• CPC Class Codes: A61K 49/0008 Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
• CPC Class Codes: A61K 49/006 Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 31/22 for herpes viruses
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/52 Cytokines; Lymphokines; Interferons
• CPC Class Codes: C07K 16/244 Interleukins [IL]
• CPC Class Codes: C07K 16/2803 against the immunoglobulin superfamily
• CPC Class Codes: C07K 2317/76 Antagonist effect on antigen, e.g. neutralization or inhibition of binding
• CPC Class Codes: G01N 33/505 involving T-cells
• CPC Class Codes: G01N 33/6869 : Interleukin
• CPC Class Codes: G01N 33/6881 : from skin

Abstract

The present invention relates to methods of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cell. In particular, diseases or disorders including contact dermatitis, drug induced delayed type cutaneous allergic reactions, toxic epidermal necrolysis, cutaneous T cell lymphoma, bullous pemphigoid, alopecia aereata, vitiligo, acne rosacea, prurigo nodularis, and herpes simplex virus, or combination thereof will benefit from the administration of an IL-31 antagonist. The invention also includes methods of predicting a therapeutically responsive patient population.

Claims

1. A method of treating a skin disorder characterized by cutaneous lymphocyte antigen positive T cells in a mammal comprising administering to the mammal a therapeutically effective amount of a neutralizing monoclonal antibody or antibody fragment thereof which specifically binds to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:

2, wherein the skin disorder is pruritis associated with cutaneous T cell lymphoma, and wherein after administration the skin disorder is improved.

2. The method of claim 1, wherein the neutralizing monoclonal antibody or antibody fragment is (a) a murine monoclonal antibody, (b) a humanized antibody derived from (a), (c) a chimeric antibody fragment, (d) a human monoclonal antibody;

or (e) a single chain antibody.

3. The method of claim 1, wherein the antibody fragment is selected from the group consisting of:

a) a Fab fragment;

b) a Fab′

fragment;

c) a Fv fragments;

d) a F(ab′

)₂ fragment; and

e) a single chain antibody fragment.

4. A method of treating a skin disorder characterized by cutaneous lymphocyte antigen positive T cells in a mammal comprising administering to the mammal a therapeutically effective amount of a composition comprising a neutralizing monoclonal antibody or antibody fragment thereof and a pharmaceutically acceptable carrier, wherein the neutralizing monoclonal antibody or antibody fragment specifically binds to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:

2, wherein the skin disorder is pruritis associated with cutaneous T cell lymphoma, and wherein after administration the skin disorder is improved.

5. The method of claim 4, wherein the neutralizing monoclonal antibody or antibody fragment is (a) a murine monoclonal antibody, (b) a humanized antibody derived from (a), (c) a chimeric antibody fragment, (d) a human monoclonal antibody;

or (e) a single chain antibody.

6. The method of claim 4, wherein the antibody fragment is selected from the group consisting of:

a) a Fab fragment;

b) a Fab′

fragment;

c) a Fv fragments;

d) a F(ab′

)₂ fragment; and

e) a single chain antibody fragment.