Compositions and Methods of Treating Metabolic Disorders
First Claim
1. A method of improving the gastrointestinal tolerability of and/or reducing gastrointestinal complications resulting from biguanide administration, comprising administering a therapeutically effective amount of a biguanide compound in a delayed-release formulation to a patient in need thereof.
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Accused Products
Abstract
Methods for improving the gastrointestinal tolerability of biguanide compounds and for treating metabolic disorders and/or inducing weight loss in patients in need thereof, particularly in individuals having a contraindication for treatment with biguanide compounds, are provided comprising administering delayed release formulations of such biguanide compounds, including metformin, targeted to the small intestine.
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Citations
25 Claims
- 1. A method of improving the gastrointestinal tolerability of and/or reducing gastrointestinal complications resulting from biguanide administration, comprising administering a therapeutically effective amount of a biguanide compound in a delayed-release formulation to a patient in need thereof.
- 2. A method of treating metabolic disorders in a patient in need thereof, comprising administering a therapeutically effective amount of a biguanide compound to said patient in a delayed-release formulation, wherein said patient has a contraindication for the biguanide compound.
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12. A method of treating a renally impaired subject having diabetes, comprising administering a therapeutically effective amount of a biguanide compound to said subject in a delayed-release formulation.
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13. A method of treating a diabetic subject having congestive heart failure, a hypoxic state and/or advanced liver disease, comprising administering a therapeutically effective amount of a biguanide compound to said subject in a delayed-release formulation.
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14. A method of reducing the onset of diabetes in a subject with pre-diabetes, comprising administering a therapeutically effective amount of a biguanide compound to said subject in a delayed-release formulation.
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15. A method of inducing weight loss in a subject, comprising administering a therapeutically effetive amount of a biguanide compound to said subject in a delayed release formulation.
Specification