METHODS AND COMPOSITIONS FOR REGULATION OF TRANSGENE EXPRESSION
First Claim
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1. A non-naturally occurring fusion protein comprising a zinc finger protein that binds to an endogenous albumin gene and a cleavage domain, wherein the fusion protein modifies the endogenous albumin gene.
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Abstract
Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
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Citations
14 Claims
- 1. A non-naturally occurring fusion protein comprising a zinc finger protein that binds to an endogenous albumin gene and a cleavage domain, wherein the fusion protein modifies the endogenous albumin gene.
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2. The fusion protein of claim 2, wherein the zinc finger protein comprises 4, 5 or 6 zinc finger domains comprising a recognition helix region, wherein the zinc finger proteins comprise the recognition helix regions shown in a single row of Table 1, Table 3, Table 5 or Table 8.
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