STABILIZED POLYMERS FOR USE WITH ANALYTE SENSORS AND METHODS FOR MAKING AND USING THEM

• US 20130178726A1
• Filed: 01/05/2012
• Published: 07/11/2013
• Est. Priority Date: 01/05/2012
• Status: Abandoned Application

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Wang, Jenn-Hann Larry, Cochran, Brooks B., Dang, Tri T., Shah, Rajiv
• Application Number:
  US13/344,343
• Publication Number:
  US 20130178726A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: C08G 77/458 containing polyurethane sequences
• CPC Class Codes: C08K 5/13 Phenols; Phenolates
• CPC Class Codes: C08L 75/00 Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
• CPC Class Codes: C12Q 1/002 Electrode membranes

Abstract

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.

Claims

1. A composition of matter comprising a polymer formed from a mixture comprising:

a diisocyanate;

a siloxane;

a hydrophilic diol or hydrophilic diamine; and

a polymer stabilizing compound, wherein the polymer stabilizing compound;

has a molecular weight of less than 1000 g/mol;

comprises a benzyl ring having at least one hydroxyl moiety (ArOH).

2. The composition of claim 1, wherein the polymer is formed from a mixture comprising:

45-55 mol % diisocyanate;

10-20 mol % siloxane;

30-45 mol % hydrophilic diol or hydrophilic diamine; and

0.1-5 weight % polymer stabilizing compound.

3. The composition of claim 1, wherein the wherein the polymer stabilizing compound comprises at least two benzyl rings having at least one hydroxyl moiety.

4. The composition of claim 1, wherein the polymer stabilizing compound comprises:

pyrogallol;

catechol;

2,2′

-Methylenebis (6-tert-butyl-4-methylphenol;

2,2′

-Ethylene-bis(4,6-di-tert-butylphenol);

or

4,4′

-Methylenebis(2,6-di-tert-butylphenol).

5. The composition of claim 1, wherein the polymer stabilizing compound is covalently coupled at one or both ends of the polymer.

6. The composition of claim 1, wherein the polymer stabilizing compound is:

not covalently coupled to the polyurethane/polyurea polymer; and

entrapped within a plurality of polyurethane/polyurea polymers.

7. The composition of claim 1, further comprising a platinum or iridium composition, wherein the polymer coats the platinum or iridium composition.

8. The composition of claim 1, wherein the polymer exhibits increased permeability to glucose as compared to a formulation of polymer lacking the stabilizing compound.

9. The composition of claim 1, wherein the polymer is further mixed with a branched acrylate polymer;

at a ratio of between 1;

1 and 1;

20 by weight %.

12. The analyte sensor system of claim 1, wherein the polyurethane/polyurea polymer stabilizing compound is covalently coupled to the polyurethane/polyurea polymer.

10. An analyte sensor system comprising:

a probe adapted to be inserted in vivo, wherein the probe includes an electrode array comprising;

a working electrode, a counter electrode; and

a reference electrode;

an analyte sensing layer disposed on the working electrode;

an analyte modulating layer disposed on the analyte sensing layer, wherein the analyte modulating layer comprises a polyurethane/polyurea polymer formed from a mixture comprising;

(a) a diisocyanate;

(b) a hydrophilic polymer comprising a hydrophilic diol or hydrophilic diamine;

(c) a siloxane having an amino, hydroxyl or carboxylic acid functional group at a terminus; and

(d) a polyurethane/polyurea polymer stabilizing compound selected for its ability to inhibit thermal and oxidative degradation of polyurethane/polyurea polymers formed from the mixture, wherein the polyurethane/polyurea polymer stabilizing compound;

has a molecular weight of less than 1000 g/mol;

comprises a benzyl ring having at least one hydroxyl moiety (ArOH).

11. The analyte sensor system of claim 10, wherein the analyte modulating layer comprising the polyurethane/polyurea polymer stabilizing compound exhibits an increased permeability to glucose as compared to analyte modulating layer not comprising the polyurethane/polyurea polymer stabilizing compound.

13. The analyte sensor system of claim 10, wherein the polyurethane/polyurea polymer stabilizing compound is:

not covalently coupled to the polyurethane/polyurea polymer; and

entrapped within a plurality of polyurethane/polyurea polymers.

14. The analyte sensor system of claim 10, wherein the polyurethane/polyurea polymer stabilizing compound exhibits an antioxidant activity.

15. The analyte sensor system of claim 10, wherein the wherein the polyurethane/polyurea polymer stabilizing compound comprises at least two benzyl rings having at least one hydroxyl moiety.

16. The analyte sensor system of claim 10, wherein the wherein the polyurethane/polyurea polymer stabilizing compound is:

pyrogallol;

catechol;

2,2′

-Methylenebis(6-tert-butyl-4-methylphenol;

2,2′

-Ethylene-bis(4,6-di-tert-butylphenol);

or

4,4′

-Methylenebis (2,6-di-tert-butylphenol).

17. The analyte sensor system of claim 10, wherein the polyurethane/polyurea polymer comprises:

45-55 mol % diisocyanate;

10-20 mol % siloxane;

30-45 mol % hydrophilic diol or hydrophilic diamine; and

0.1-5 weight % polyurethane/polyurea polymer stabilizing compound.

18. The analyte sensor system of claim 10, wherein the polyurethane/polyurea polymer stabilizing compound comprises a benzyl ring having at least two hydroxyl moieties.

19. The analyte sensor system of claim 10, further comprising at least one of:

an interference rejection membrane;

a protein layer;

an adhesion promoting layer disposed on the analyte sensing layer, wherein the adhesion promoting layer promotes the adhesion between the analyte sensing layer and the analyte modulating layer;

or

a cover layer wherein the cover layer comprises an aperture positioned on the cover layer so as to facilitate an analyte present in the mammal contacting and diffusing through an analyte modulating layer; and

contacting the analyte sensing layer.

20. The analyte sensor system of claim 10, further comprising a probe platform and wherein the first probe comprises:

a first electrode array comprising a working electrode, a counter electrode and a reference electrode; and

a second electrode array comprising a working electrode, a counter electrode and a reference electrode;

a second probe coupled to the probe platform and adapted to be inserted in vivo, wherein the second probe comprises;

a third electrode array comprising a working electrode, a counter electrode and a reference electrode; and

a fourth electrode array comprising a working electrode, a counter electrode and a reference electrode;

wherein the first, second, third and fourth electrode arrays are configured to be electronically independent of one another.