TISSUE PROFILE WELLNESS MONITOR

• US 20130178749A1
• Filed: 02/11/2013
• Published: 07/11/2013
• Est. Priority Date: 04/21/2007
• Status: Active Grant

• Current Assignee: Masimo Corporation
• Original Assignee: Cercacor Laboratories
• Inventors: Lamego, Marcelo
• Granted Patent: US 8,965,471 B2
• Time in Patent Office: Days
• US Class Current: 600/479
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/7405 using sound
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick

Abstract

A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.

Claims

1. A physiological monitoring method comprising:

emitting a plurality of wavelengths of light into a tissue site of a patient including pulsating blood;

detecting the light after attenuation by the tissue site;

normalizing at each of at least two of the plurality of wavelengths of light;

generating a tissue profile in response to the normalized plurality of wavelengths using a processor; and

analyzing the tissue profile using the processor to determine a patient wellness.

2. The physiological monitoring method of claim 1, wherein analyzing comprises:

determining whether the tissue profile is within predetermined boundaries, the predetermined boundaries indicative of patient wellness.

3. The physiological monitoring method of claim 2, wherein patient wellness is determined based at least in part on the shape of the tissue profile.

4. The physiological monitoring method of claim 2, wherein determining comprises:

dividing the tissue profile into a head portion and a tail portion; and

evaluating the head portion separately from the tail portion, wherein the head portion is compared to predetermined head boundaries, and the tail portion is compared to predetermined tail boundaries.

5. The physiological monitoring method of claim 1, wherein measuring a physiological parameter and generating a tissue profile are each performed repeatedly.

6. The physiological monitoring method of claim 5, wherein analyzing comprises, for each generated tissue profile:

dividing the tissue profile into a head portion and a tail portion;

comparing the head portion to a head boundary; and

comparing the tail portion to a tail boundary.

7. The physiological monitoring method of claim 6, wherein analyzing further comprises, for each generated tissue profile:

comparing a rate of change of the head portion to a head trend limit; and

comparing a rate of change of the tail portion to a tail trend limit.

8. The physiological monitoring method of claim 7, further comprising:

outputting a first signal indicative of patient normalcy when the head portion is within the head boundary and changing more slowly than the head trend limit and the tail portion is within the tail boundary and changing more slowly than the tail trend limit;

outputting a second signal indicative of caution when at least one of the head portion is changing more quickly than the head trend limit and the tail portion is changing more quickly than the tail trend limit; and

outputting a third signal indicative of high alert when at least one of the head portion is outside the head boundary and the tail portion is outside the tail boundary.

9. A patient monitoring device for generating and analyzing a tissue profile, the device comprising:

a sensor comprising a light source that emits a plurality of wavelengths of light into a tissue site of a patient and a detector that detects the emitted light after attenuation by the tissue site; and

a patient monitor in communication with the sensor, the patient monitor configured to;

generate a tissue profile responsive to absorption of at least some of the emitted wavelengths using a processor; and

analyze the tissue profile using the processor to determine patient wellness.

10. The patient monitoring device of claim 9, wherein the patient wellness is determined based at least in part on the shape of the tissue profile.

11. The patient monitoring device of claim 10, wherein patient wellness is indicated by at least one of a display, an alarm, diagnostic and a control.

12. The patient monitoring device of claim 9, wherein, in order to generate a tissue profile, the patient monitor is further configured to:

measure values at each of at least some of the emitted wavelengths;

define additional values corresponding to at least a portion of a wavelength spectrum between the at least some emitted wavelengths based on characteristics of the tissue site; and

normalize the measured values and additional values with respect to a reference wavelength.

13. The patient monitoring device of claim 12, wherein, in order to analyze the tissue profile shape, the patient monitor is further configured to:

set a limit corresponding to the tissue profile; and

specify an output corresponding to a comparison of the tissue profile to the set limit.

14. The patient monitoring device of claim 13, wherein, in order to set a limit, the patient monitor is further configured to:

define at least one of a boundary and a maximum rate of change for at least a portion of the tissue profile.

15. The patient monitoring device of claim 14, wherein the patient monitor is further configured to:

output a first signal indicative of patient normalcy when the tissue profile is within the boundary and the tissue profile rate of change is less than the maximum rate of change; and

output a second signal indicative of alert when at least one of the tissue profile is outside of the boundary and the tissue profile rate of change is greater than the maximum rate of change.

16. A method of providing advance warning of deteriorating patient wellness, the method comprising:

transmitting multiple wavelengths of light through a tissue site of a patient;

measuring an attenuation by the tissue site of each of the wavelengths of transmitted light;

determining, for each measured attenuation of each wavelength of transmitted light, a normalized plethysmograph (NP);

selecting a reference wavelength from the multiple transmitted wavelengths;

calculating a wellness indicator by normalizing the NP of each wavelength by the NP of the reference wavelength; and

comparing the calculated wellness indicator to predetermined limits, wherein the wellness indicator exceeding the predetermined limits indicates advance warning of deteriorating patient wellness.

17. The method of claim 16, wherein the reference wavelength divides the wellness indicator into a first portion and a second portion, and wherein the first portion is compared to a first portion predetermined limit, and the second portion is compared to a second portion predetermined limit.

18. The method of claim 16, further comprising:

defining continuous normalized NP values corresponding to at least a portion of a wavelength spectrum between the two or more of the multiple transmitted wavelengths based at least in part on characteristics of the tissue site; and

calculating a continuous wellness indicator by combining the normalized NP values at each transmitted wavelength with the defined continuous normalized NP values.