Individualized Dosing Technique With Multiple Variables
First Claim
1. A method of determining a dose of anti-coagulant drug for a patient in need of anti-coagulant therapy to obtain a specific International Normalized Ratio comprising the steps of:
- a) conducting a patient intake by a health care professional comprising questions concerning health factors;
current average daily dose of anti-coagulant drug in milligrams,current international normalized ratio value,patient'"'"'s weight in kilograms,patient'"'"'s temperature,number of episodes of fevers,number of episodes of diarrhea,amount and type of alcohol ingested,current prescription drugs, including dosage, frequency and route of intake,percent compliance of taking anti-coagulant drug,kidney function,liver function,amount and type of Vitamin K containing food eaten, and any change in the intake of these foods,number of bleeding episodes since last visit, andnumber of clotting episodes since last visit;
b) recording the answers in step a) into a questionnaire to obtain values representing each category of question in step a);
c) entering the values from step b) into a mathematical model;
d) generating an equation of a line representing the relationship between the dose amount of the anti-coagulant drug and the INR in the patient;
e) using the equation generated in step d) to calculate the daily dose of the anti-coagulant drug to obtain the desired therapeutic INR score.
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Abstract
A method to quantify and correct for drug-drug interaction, physiologic change, diet, weight, genetic data and compliance on Warfarin dosing. The International Normalized Ratio (INR), a lab value used to follow Warfarin use, will fluctuate in an unpredictable manner due to factors other than the current Warfarin dose. The method mathematically describes these changes and eventually adjusts for these interacting factors through the use of logistic regression (LR) or multiple linear regression analysis. By anticipating changes in INR, Warfarin dosing can be adjusted resulting in patients having their INR be therapeutic range. The technique can be used in any field that requires a specific measured quantity, with variables that change and the need to correct for changes with a mathematical model.
7 Citations
21 Claims
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1. A method of determining a dose of anti-coagulant drug for a patient in need of anti-coagulant therapy to obtain a specific International Normalized Ratio comprising the steps of:
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a) conducting a patient intake by a health care professional comprising questions concerning health factors; current average daily dose of anti-coagulant drug in milligrams, current international normalized ratio value, patient'"'"'s weight in kilograms, patient'"'"'s temperature, number of episodes of fevers, number of episodes of diarrhea, amount and type of alcohol ingested, current prescription drugs, including dosage, frequency and route of intake, percent compliance of taking anti-coagulant drug, kidney function, liver function, amount and type of Vitamin K containing food eaten, and any change in the intake of these foods, number of bleeding episodes since last visit, and number of clotting episodes since last visit; b) recording the answers in step a) into a questionnaire to obtain values representing each category of question in step a); c) entering the values from step b) into a mathematical model; d) generating an equation of a line representing the relationship between the dose amount of the anti-coagulant drug and the INR in the patient; e) using the equation generated in step d) to calculate the daily dose of the anti-coagulant drug to obtain the desired therapeutic INR score. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of determining a dose of a drug for a patient in need of long-term therapy to obtain a specific laboratory test value comprising the steps of:
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a) conducting a patient intake by a health care professional comprising questions concerning health factors; current average daily dose of drug in milligrams, current laboratory test value, patient'"'"'s weight in kilograms, patient'"'"'s temperature, number of episodes of fevers, number of episodes of diarrhea, amount and type of alcohol ingested, current medications, including dosage, frequency and route of intake, percent compliance of taking drug, kidney function, liver function, amount and type of food eaten, and any change in the intake of these foods, and number of adverse episodes since last visit; b) recording the answers in step a) into a questionnaire to obtain values representing each category of question in step a); c) entering the values from step b) into a mathematical model; d) generating an equation of a line representing the relationship between the dose amount of the drug and the laboratory test value; e) using the equation generated in step d) to calculate the daily dose of the drug to obtain the desired laboratory test value. - View Dependent Claims (20, 21)
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Specification