CARTRIDGE AND AUTOMATIC ANALYSIS DEVICE

• US 20130183769A1
• Filed: 09/20/2011
• Published: 07/18/2013
• Est. Priority Date: 09/17/2010
• Status: Abandoned Application

• Current Assignee: Universal Bio Research Co., Ltd (Precision System Science Co., Ltd)
• Original Assignee: Universal Bio Research Co., Ltd (Precision System Science Co., Ltd)
• Inventors: Tajima, Hideji
• Application Number:
  US13/821,309
• Publication Number:
  US 20130183769A1
• Time in Patent Office: Days
• US Class Current: 436/165
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 2300/0858 Side walls
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: G01N 2021/0325 Cells for testing reactions, e.g. containing reagents
• CPC Class Codes: G01N 2021/0328 Arrangement of two or more cells having different functions for the measurement of reactions
• CPC Class Codes: G01N 2021/0378 Shapes
• CPC Class Codes: G01N 2021/0382 Frustoconical, tapered cell
• CPC Class Codes: G01N 2021/0389 Windows
• CPC Class Codes: G01N 2035/00148 Test cards, e.g. Biomerieux or McDonnel multiwell test cards
• CPC Class Codes: G01N 2035/00801 Holders for sample carriers, e.g. trays, caroussel, racks
• CPC Class Codes: G01N 2035/0436 with pre-packaged reagents, i.e. test-packs
• CPC Class Codes: G01N 21/01 Arrangements or apparatus for facilitating the optical investigation
• CPC Class Codes: G01N 21/03 Cuvette constructions
• CPC Class Codes: G01N 21/0303 Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment G01N21/031 - G01N21/15 take precedence
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/00732 Identification of carriers, materials or components in automatic analysers

Abstract

Provided is a reagent accommodating/measuring cartridge for mixing and reacting a test specimen with a reagent and for measuring the reaction state thereof with the transmitted light, the cartridge comprising a plurality of transmitted-light measurement chambers having different optical path lengths.

Claims

1. A reagent accommodating/measuring cartridge for mixing and reacting a test specimen with a reagent and for measuring the reaction state thereof with the transmitted light, the cartridge comprising a plurality of transmitted-light measurement chambers with different optical path lengths.

2. The cartridge according to claim 1, further comprising a specimen-accommodating chamber for accommodating a test specimen, a chip-accommodating chamber for accommodating a pipette chip and a tool-accommodating chamber for accommodating a seal-breaking tool.

3. The cartridge according to claim 1, further comprising an identifier for recording information on operational processes including mixing the test specimen with the reagent through outputting measurement results

4. The cartridge according to claim 1, comprising means for displaying reagent information that designates a chamber that gives the highest measurement effect among the plurality of transmitted-light measurement chambers.

5. The cartridge according to claim 1, wherein at least one of the plurality of transmitted-light measurement chambers serves as a reservoir for the reagent or the test specimen.

6. The cartridge according to claim 1, wherein the transmitted-light measurement chamber has transmittance of 70% or higher in the range of 340-800 nm.

7. The cartridge according to claim 1, wherein the transmitted-light measurement chamber is made of cyclic polyolefin.

8. The cartridge according to claim 1, wherein a reagent is placed and sealed in at least one of the plurality of transmitted-light measurement chambers in advance.

9. The cartridge according to claim 3 wherein, among the specimen-accommodating chamber, the chip-accommodating chamber, the tool-accommodating chamber and the identifier, at least the identifier is covered with a seal.

10. The cartridge according to claim 9, wherein the specimen-accommodating chamber, the chip-accommodating chamber, the tool-accommodating chamber and the identifier are covered with a seal.

11. An automatic analysis device mounted with the cartridge according to claim 1, the automatic analysis device comprising:

a nozzle having a pipette chip at the tip, for withdrawing the test specimen into the pipette chip and discharging the test specimen to dispense the test specimen into the reagent chamber;

a light source for radiating light to a mixture of the test specimen and the reagent; and

a detector for receiving the light from the light source through the mixture, wherein the dispensing nozzle, the light source and the detector are integrally mounted on the same movable unit.

12. The automatic analysis device according to claim 11, further comprising, in the same unit, a filter for adjusting the wavelength-intensity distribution of the light from the light source.

13. The automatic analysis device according to claim 11, wherein the withdrawal and discharge sites of the dispensing nozzle are positioned along the optical axis extending between the light source and the detector.

14. The automatic analysis device according to claim 11, wherein the automatic analysis device has a mechanism for dispersing the light received with the detector, and measuring the intensity of the dispersed light at each wavelength band independently.

15. The automatic analysis device according to claim 11 wherein the wavelength of the light for irradiating the mixture is 340 nm to 800 nm.

16. The automatic analysis device according to claim 11, comprising a mechanism for reading out operational processes from the cartridge.

19. A method for sealing the cartridge according to claim 3, comprising a step of covering at least the identifier with a seal.

22. A method for automatically analyzing a test specimen, comprising a step of installing the cartridge according to claim 1 into the automatic analysis device according to claims 11 to measure the test specimen contained in the cartridge.

17. A cartridge comprising:

a chamber for accommodating a tool for treating a test specimen and a reagent, and/or a chamber or a well for subjecting the test specimen and the reagent to a treatment; and

an identifier for recording information on the procedure of the treatment, wherein at least the identifier is covered with a seal.

18. The cartridge according to claim 17, wherein the chamber, the well and the identifier are covered with a seal.

23. A method for automatically analyzing a test specimen, comprising a step of installing the cartridge according to claim 17 into the automatic analysis device for measuring a test specimen to measure the test specimen contained in the cartridge.

20. A method for sealing a cartridge,

wherein the cartridge comprises:

(a) a chamber for accommodating a tool for treating a test specimen and a reagent, and/or a chamber or a well for subjecting the test specimen and the reagent to a treatment; and

(b) an identifier for recording information on the procedure of the treatment, and wherein the method comprises a step of covering at least the identifier with a seal.

21. The method according to claim 20, wherein the chamber, the well and the identifier are covered with a seal.