Implantable Devices And Methods For The Evaluation of Active Agents
First Claim
1. An implantable microdevice comprisinga support structure having on the surface thereof a plurality of microwells formed on or within the support structure,the device having dimensions that permit implantation into a tissue using a catheter, cannula, or biopsy needle,optionally comprising a guidewire attached to a proximal end of the device, one or more sensors integrated within the device or microwells, and fiber optic or other addressible or interactive means for remote interrogation of the device.
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Accused Products
Abstract
Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure. The microwells contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility (such as WiFi) to provide for in situ retrieval of information and modification of device release properties. In the most preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.
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Citations
19 Claims
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1. An implantable microdevice comprising
a support structure having on the surface thereof a plurality of microwells formed on or within the support structure, the device having dimensions that permit implantation into a tissue using a catheter, cannula, or biopsy needle, optionally comprising a guidewire attached to a proximal end of the device, one or more sensors integrated within the device or microwells, and fiber optic or other addressible or interactive means for remote interrogation of the device.
Specification