SYSTEMS AND METHODS FOR ASSESSING AND EXPLOITING CONCURRENT CATHODAL AND ANODAL CAPTURE USING AN IMPLANTABLE MEDICAL DEVICE

• US 20130184777A1
• Filed: 01/17/2012
• Published: 07/18/2013
• Est. Priority Date: 01/17/2012
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Hellman, Heidi, Ryu, Kyungmoo
• Granted Patent: US 9,002,455 B2
• Time in Patent Office: Days
• US Class Current: 607/28
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7242 using integration
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Techniques are provided for use by an implantable medical device for assessing and controlling concurrent anodal/cathodal capture. In one example, the device delivers bipolar pacing stimulus while sensing a bipolar intracardiac electrogram (IEGM) and while adjusting a magnitude of the pacing stimulus. The device analyzes the bipolar IEGM signals to detect an indication of activation representative of concurrent anodal and cathodal capture. Preferably, the pulse magnitude is set relative to the anodal/cathodal capture threshold based upon clinician programming in response to the needs of the patient. In this manner, concurrent anodal and cathodal capture can be selectively activated or deactivated based on clinician instructions received from a device programmer or other external programming device. Techniques exploiting both bipolar and unipolar IEGM signals to assess and control concurrent anodal/cathodal capture are also described. Techniques for use with quad-pole leads to achieve dual-site or quad-site capture are also set forth.

Claims

1. A method for use with an implantable medical device equipped for bipolar electrical stimulation and sensing of heart tissues using cardiac electrodes, the method comprising:

delivering bipolar stimulus using a pair of the cardiac electrodes while sensing bipolar intracardiac electrogram (IEGM) signals using the pair of the cardiac electrodes;

detecting an indication within the bipolar IEGM signals of evoked responses (ERs) representative of anodal capture within myocardial tissues associated with an anode of the pair of the cardiac electrodes and cathodal capture within myocardial tissues associated with a cathode of the pair of the cardiac electrodes; and

determining an anodal/cathodal capture threshold sufficient to achieve both anodal and cathodal capture from the indication within the bipolar IEGM signals of the ERs.

2. The method of claim 1 furthering including setting a magnitude for subsequent bipolar stimulus relative to the anodal/cathodal capture threshold to selectively enable the anodal and cathodal capture.

3. The method of claim 1 wherein the magnitude for subsequent bipolar stimulus is set above the anodal/cathodal capture threshold to enable the anodal and cathodal capture with a single stimulus pulse.

4. The method of claim 2 further including analyzing subsequent bipolar IEGM signals to confirm the anodal and cathodal capture during subsequent bipolar stimulation by detecting additional ERs representative of the anodal and cathodal capture.

5. The method of claim 2 wherein the magnitude for subsequent bipolar stimulus is set below the anodal/cathodal capture threshold to disable anodal capture.

6. The method of claim 1 wherein the detecting an indication within the bipolar IEGM signals of ERs includes:

incrementing a magnitude of the bipolar stimulus while detecting the ERs within the bipolar IEGM signals;

detecting a stimulus magnitude above which the ERs within the bipolar IEGM signals decrease from a high ER associated with cathodal-only capture to a low ER associated with the anodal and cathodal capture.

7. The method of claim 6 wherein, if unable to detect the indication within the bipolar IEGM signals of ERs representative of both the anodal and cathodal capture within a predetermined range of acceptable stimulus magnitudes, repeating the delivering and detecting with another bipolar pair of electrodes.

8. The method of claim 1 wherein the detecting an indication within the bipolar IEGM signals of ERs includes:

decrementing a magnitude of the bipolar stimulus from a maximum permissible magnitude while detecting the ERs within the bipolar IEGM signals;

detecting a stimulus magnitude below which the ERs within the bipolar IEGM signals increase from a low ER associated with the anodal and cathodal capture to a high ER associated with cathodal-only capture.

9. The method of claim 1 further comprising analyzing the bipolar IEGM signals to additionally detect a cathodal-only capture threshold sufficient to achieve the cathodal capture without the anodal capture.

10. The method of claim 9 wherein a magnitude for subsequent stimulus is set above the cathodal-only capture threshold but below the anodal/cathodal capture threshold to achieve cathodal-only capture.

11. The method of claim 1 further including:

sensing unipolar IEGM signals using one of the pair of the cardiac electrodes as a cathode and a device housing electrode as an anode while the bipolar stimulus is delivered; and

comparing the bipolar IEGM signals to the unipolar IEGM signals to detect the anodal/cathodal capture threshold.

12. The method of claim 1 further including:

sensing unipolar IEGM signals using one of the pair of the cardiac electrodes as a cathode and a device housing electrode as an anode while the bipolar stimulus is delivered; and

comparing the bipolar IEGM signals to the unipolar IEGM signals to confirm the anodal and cathodal capture during subsequent stimulation.

13. The method of claim 12 wherein confirming the anodal and cathodal capture during subsequent stimulus includes:

comparing the bipolar IEGM signals associated with stimulus pulses delivered above the anodal/cathodal capture threshold with corresponding unipolar IEGM signals; and

confirming that the unipolar IEGM signals exhibit greater ERs than the bipolar IEGM signals as expected with the anodal and cathodal capture.

14. The method of claim 1 for use with an implantable medical device equipped with a multi-polar left ventricular (LV) lead and further comprising:

determining a first amount of energy required to achieve dual-site capture within the left ventricle using a single simulation pulse sufficient to achieve the anodal and cathodal capture using a selected pair of electrodes of the LV lead;

determining a second amount of energy required to achieve dual-site capture within the left ventricle using a pair of simulation pulses, each individual pulse sufficient to achieve cathodal-only capture at a respective one of the selected pair of electrodes of the LV lead; and

selecting a pacing mode for achieving the dual-site capture based on a comparison of the first and second amounts of energy.

15. The method of claim 1 for use with an implantable medical device equipped with a quad-polar left ventricular (LV) lead wherein separate anodal/cathodal capture thresholds are determined for two separate pairs of electrodes of the LV lead.

16. The method of claim 15 further comprising:

determining a first amount of energy required to achieve quad-site capture within the left ventricle using a pair of simulation pulses, each sufficient to achieve the anodal and cathodal capture at a respective pair of electrodes of the LV lead;

determining a second amount of energy required to achieve quad-site capture within the left ventricle using two pair of simulation pulses, delivered in succession, each individual pulse sufficient to achieve cathodal-only capture at one of the electrodes of the LV lead; and

selecting a pacing mode for achieving the quad-site capture based on a comparison of the first and second amounts of energy.

17. The method of claim 1 wherein the delivering, detecting, and determining are performed by the implantable medical device.

18. The method of claim 1 wherein at least some of the delivering, detecting, and determining are performed by an external device in communication with the implantable medical device.

19. The method of claim 1 wherein the bipolar stimulus comprises any stimulus wherein both an anodal electrode and a cathodal electrode of the pair of the cardiac electrodes are implanted on or within a heart.

20. The method of claim 19 wherein the bipolar stimulus includes single chamber stimulus wherein both the anodal electrode and the cathodal electrode are implanted on or within a same chamber of the heart.

21. The method of claim 19 wherein the bipolar stimulus includes cross-chamber stimulus wherein the anodal electrode and the cathodal electrode are implanted on or within different chambers of the heart.

22. The method of claim 1 wherein the detecting an indication within the bipolar IEGM signals of ERs representative of the anodal and cathodal capture is performed to detect an indication of concurrent ERs.

23. A system for use with an implantable medical device equipped for bipolar electrical stimulation and sensing of heart tissues using cardiac electrodes, the system comprising:

a bipolar stimulus controller operative to control delivery of bipolar stimulus using a pair of cardiac electrodes while sensing bipolar intracardiac electrogram (IEGM) signals using the pair of cardiac electrodes;

an evoked response (ER) detection system operative to detect an indication within the bipolar IEGM signals of ERs representative of anodal capture within myocardial tissues associated with an anode of the pair of cardiac electrodes and cathodal capture within myocardial tissues associated with a cathode of the electrode pair of cardiac electrodes; and

an anodal/cathodal capture threshold determination system operative to determine the anodal/cathodal capture threshold sufficient to achieve both anodal and cathodal capture from the indication within the bipolar IEGM signals of the ERs.

24. The system of claim 23 further comprising:

an anodal/cathodal stimulus controller operative to set a magnitude for subsequent stimulus to selectively enable the anodal and cathodal capture.

25. A system for use with an implantable medical device equipped for bipolar electrical stimulation and sensing of heart tissues using cardiac electrodes, the system comprising:

means for delivering bipolar stimulus using a pair of the cardiac electrodes while sensing bipolar intracardiac electrogram (IEGM) signals using the pair of the cardiac electrodes;

means for detecting an indication within the bipolar IEGM signals of evoked responses (ERs) representative of anodal capture within myocardial tissues associated with an anode of the pair of the cardiac electrodes and cathodal capture within myocardial tissues associated with a cathode of the pair of the cardiac electrodes; and

means for determining an anodal/cathodal capture threshold sufficient to achieve both anodal and cathodal capture from the indication within the bipolar IEGM signals of the ERs.