BIOABSORBABLE ENCLOSURES

• US 20130184826A1
• Filed: 12/21/2012
• Published: 07/18/2013
• Est. Priority Date: 12/22/2011
• Status: Abandoned Application

• Current Assignee: Basix Spine, LLC
• Original Assignee: Basix Spine, LLC
• Inventors: Thaiyananthan, Gowriharan
• Application Number:
  US13/724,580
• Publication Number:
  US 20130184826A1
• Time in Patent Office: Days
• US Class Current: 623/17.16
• CPC Class Codes: A61B 17/7059 Cortical plates A61B17/7007, A61B17/7058 take precedence
• CPC Class Codes: A61B 17/7062 Devices acting on, attached to, or simulating the effect of, vertebral processes, vertebral facets or ribs rib fixation devices A61B17/8076; Tools for such devices
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61F 2/30907 Nets or sleeves applied to surface of prostheses or in cement
• CPC Class Codes: A61F 2/442 Intervertebral or spinal discs, e.g. resilient non-disc-shaped intervertebral inflatable pockets A61F2/441; non-disc-shaped intervertebral fusion implants A61F2/4455
• CPC Class Codes: A61F 2/4455 for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages intervertebral discs A61F2/442
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure

Abstract

Provided are bioabsorbable enclosures for use in spinal surgical procedures such as fusion of spinal vertebrae. Also provided are methods for enhancing fusion of spinal vertebrae using bioabsorbable enclosures.

Claims

1. A device for implanting in the spinal region of a subject, comprising:

a deformable enclosure at least partially defined by a porous, bioabsorbable material;

wherein the enclosure is configured to retain a substance that is positioned in the enclosure for a duration of time, during which at least a portion of the substance interacts with the subject through the porous bioabsorbable material of the enclosure.

2. The device of claim 1, wherein the deformable enclosure has an opening at one end that is sized for the insertion of an interbody fusion device into the enclosure.

3. The device of claim 2, wherein an interbody fusion device is positioned within the enclosure.

4. The device of claim 3, wherein the substance comprises one or more of bone, allograft, autograft, bone paste, bone putty, a growth factor, a pharmaceutical agent, BMP or combinations thereof.

5. The device of claim 4, wherein the interbody fusion device is an anterior lumbar interbody fusion cage.

6. The device of claim 4, wherein the interbody fusion device is a posterior lumbar interbody fusion cage.

7. The device of claim 4, wherein the interbody fusion device is a lateral lumbar fusion device

8. The device of claim 4, wherein the interbody fusion device is an anterior cervical interbody fusion cage.

9. The device of claim 4, wherein the interbody fusion device is a posterior cervical interbody fusion cage.

10. The device of claim 1, wherein the porous bioabsorbable material comprises nitrocellulose, vicryl mesh, dexon mesh, amniotic membrane, placental tissue, collagen, bioabsorbable polymer, polyglycolic acid (PGA), polylactic acid (PLA), polyparadioxanone (PDS), polycaprolactone (PCL), Poly(L-lactide), Poly(D-Lactide), Poly(DL-lactide), Polyglycolide, L-lactide/DL-lactide, L-lactide/D-lactide, L-lactide/Glycolide, Lactide/Caprolactone, or DL-lactide/Glycolide.

11. The device of claim 10, wherein the bioabsorbable material comprises a factor that facilitates bone growth

13. The device of claim 1, wherein the enclosure expandable.

14. The device of claim 13, wherein the enclosure is configured to expand upon administration of the substance into the enclosure.

15. The devise of claim 14, wherein the expanded enclosure defines an H-shaped expanded enclosure.

16. The device of claim 14, wherein the expanded enclosure has a length dimension, a width dimension and a height dimension.

17. The device of claim 16, wherein the height of the expanded enclosure is between about 0.5 millimeter (mm) and 25.0 millimeters (mm).

18. The device of claim 17, wherein the width dimension of the expanded enclosure is between about 1.0 millimeters and 50.0 millimeters.

19. The device of claim 18, wherein the length dimension of the expanded enclosure is between about 15.0 millimeters and 100.0 millimeters.

20. The device of claim 1, wherein the device is configured for placement in the lateral gutter of a lumbar spinal body.

21. The devise of claim 1, wherein the device is configured for placement in a posterior lateral element of a cervical spine.

22. The device of claim 1, wherein the enclosure defines a left and a right elongated portions and a connecting portion between the left and the right elongated portions.

23. The device of claim 22, wherein the right portion and the right portion is configured for placement in a posterior lateral element of the cervical spine.

24. The device of claim 22, wherein the right portion is configured for placement in the right lateral gutter of a lumber spinal body.

25. The device of claim 24, wherein the left portion is configured for placement in the left lateral gutter of a lumbar spinal body.

26. The device of claim 25, wherein connecting portion is configured for placement between adjacent spineous processes of two lumbar spinal bodies.

27. The device of claim 25, wherein the separation between the lateral edges of the left and right elongated portions at a given right plane across the edges is between about 10 millimeters and 100 millimeters.

29. The method of claim 22, wherein the substance promotes bone growth or bone formation in the subject.

30. The method of claim 23, wherein the substance comprises one or more of bone, allograft, autograft, bone paste, bone putty, a growth factor, a pharmaceutical agent, BMP or combinations thereof.

31. The method of claim 25, further comprising positioning an interbody fusion device in the deformable enclosure.

32. The method of claim 25, further comprising implanting the enclosure containing the interbody fusion device into the spinal region of the subject.

33. The method of claim 26, wherein the interbody fusion device is an anterior lumbar interbody fusion cage.

34. The method of claim 26, wherein the interbody fusion device is a posterior lumbar interbody fusion cage.

35. The method of claim 24, wherein at least a portion of the enclosure is positioned in a lateral gutter of a spinal body.

12. The device of claim 12, wherein the factor that facilities bone growth is a growth factor.

28. A method of enhancing spinal fusion in a subject, comprising:

providing a deformable enclosure that is at least partially defined by a porous, bioabsorbable material, wherein the enclosure is configured to retain a substance;

administering the substance into the enclosure; and

implanting the enclosure into the spinal region of the subject, wherein the substance positioned in the enclosure is retained therein for a duration of time, during which at least a portion of the substance interacts with the subject through the porous bioabsorbable material of the enclosure and wherein the interaction between the substance and the subject enhances fusion between spinal bodies, or portions thereof, of the subject.