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Electrical Resonance Detection of Particles and Analytes in Microfluidic Channels

  • US 20130187672A1
  • Filed: 02/22/2013
  • Published: 07/25/2013
  • Est. Priority Date: 02/22/2008
  • Status: Active Grant
First Claim
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1. A method of counting small objects contained in a fluid sample, comprising:

  • a. filling a sample cell with a buffer solution, the sample cell being connected in parallel with an inductance and forming an equivalent RLC circuit;

    b. applying a variable frequency current source to the sample cell and inductance;

    c. tuning the current source frequency to the resonance frequency of the equivalent RLC circuit;

    d. nulling the output of the equivalent RLC circuit;

    e. initiating a flow of test fluid through the sample cell, the test fluid containing the objects to be counted; and

    f. detecting changes in the conductivity of the sample cell as the objects pass through the sample cell.

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