COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
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Abstract
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington'"'"'s disease progression using an antisense compound targeted to huntingtin. Additionally provided are methods of delaying or preventing the onset of Huntingtin'"'"'s disease in an individual susceptible to Huntingtin'"'"'s Disease. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
18 Citations
45 Claims
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1-25. -25. (canceled)
- 26. A method of reducing expression of huntingtin mRNA in a cell, comprising contacting a cell with a modified oligonucleotide 12 to 35 nucleobases in length, wherein the antisense oligonucleotide comprises at least 12 consecutive nucleobases of a nucleotide sequence selected from the group consisting of SEQ ID NOs 48-52.
Specification