SYSTEMS AND METHODS FOR AVOIDING NEURAL STIMULATION HABITUATION

• US 20130190840A1
• Filed: 03/11/2013
• Published: 07/25/2013
• Est. Priority Date: 09/13/2007
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Libbus, Imad, Kramer, Andrew P.
• Granted Patent: US 8,694,104 B2
• Time in Patent Office: Days
• US Class Current: 607/59
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36057 adapted for stimulating afferent nerves
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer

Abstract

An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.

Claims

1. A neural stimulator, comprising:

a neural stimulation delivery system configured to stimulate a vagus nerve; and

a controller operationally connected to the neural stimulation delivery system, the controller configured to deliver a programmed neural stimulation therapy through the neural stimulation delivery system according to a programmed neural stimulation schedule, the programmed neural stimulation therapy including a stimulation signal with modifiable stimulation parameters, the modifiable stimulation parameters including at least one modifiable schedule parameter, the controller including a neural stimulation scheduler with a programmed limit for allowed modifications to the at least one modifiable schedule parameter.

2. The stimulator of claim 1, further comprising an input configured to receive an input signal, wherein the controller is configured to use the input signal to modify the at least one modifiable schedule parameter.

3. The stimulator of claim 2, wherein the input is configured to receive physician feedback, and the controller is configured to use the physician feedback to modify the at least one modifiable schedule parameter.

4. The stimulator of claim 2, wherein the input is configured to receive patient feedback, and the controller is configured to use the patient feedback to modify the at least one modifiable schedule parameter.

5. The stimulator of claim 2, wherein the input is configured to receive a physiological signal indicative of a physiological response to stimulation, and the controller is configured to use the physiological signal to modify the at least one modifiable schedule parameter.

6. The stimulator of claim 2, wherein the input is configured to receive a communication from another device to receive the physiological signal indicative of the physiological response to stimulation, and the controller is configured to use the physiological signal to modify the at least one modifiable schedule parameter.

7. The stimulator of claim 2, further comprising a sensor configured to sense a physiological parameter and provide the physiological signal indicative of the physiological response.

8. The stimulator of claim 7, wherein the sensor is a heart rate sensor, a blood pressure sensor or a respiration sensor.

9. The stimulator of claim 1, further comprising an input configured to receive an input signal, wherein the controller is configured to use the input signal to modify the programmed limit for allowed modifications to the at least one modifiable schedule parameter.

10. The stimulator of claim 9, wherein the input is configured to receive physician input, and the controller is configured to use the physician input to modify the programmed limit for allowed modifications to the at least one modifiable schedule parameter.

11. The stimulator of claim 1, wherein the programmed neural stimulation therapy is a programmed heart failure therapy.

12. The stimulator of claim 1, wherein the modifiable stimulation parameters further include at least one of a modifiable duration, a modifiable pulse width, or a modifiable frequency for the stimulation signal.

13. The stimulator of claim 1, wherein the controller is configured to deliver an intermittent stimulation signal for the programmed neural stimulation therapy, the intermittent stimulation signal including a train of neural stimulation pulses during a portion of a stimulation period and no neural stimulation pulses during another portion of the stimulation period, and the at least one modifiable neural stimulation schedule parameter includes at least one of a duty cycle of the stimulation period, a duration, or a start and stop timing for the train of neural stimulation pulses.

14. The stimulator of claim 1, wherein the controller includes a neural stimulation scheduler, the neural stimulation scheduler including a programmed limit for limiting modifications of at least one of the duty cycle of the stimulation period using a programmed maximum allowable duty cycle or a programmed allowable range for allowed modifications to the duty cycle of the stimulation period, or the duration for the train of neural stimulation pulses using a programmed minimum duration or a programmed allowable range for allowed modifications to the duration for the train of neural stimulation pulses.

15. A neural stimulator, comprising:

a neural stimulation delivery system configured to stimulate a vagus nerve, wherein the neural stimulation delivery system includes a current source pulse output circuit;

a therapy feedback sensor; and

a controller operationally connected to the neural stimulation delivery system and to the therapy feedback sensor, wherein;

the controller is configured to deliver a programmed neural stimulation therapy through the neural stimulation delivery system according to a programmed neural stimulation schedule, the programmed neural stimulation therapy including a stimulation signal with modifiable stimulation parameters, the modifiable stimulation parameters including at least one modifiable schedule parameter;

the controller is configured to receive a therapy feedback signal from the therapy feedback sensor and modify at least one modifiable stimulation parameter in response to the therapy feedback signal; and

the controller includes a neural stimulation scheduler with a programmed limit for allowed modifications to the at least one neural stimulation schedule parameter.

16. The stimulator of claim 15, wherein the therapy feedback sensor includes at least one of a blood pressure sensor, a heart rate sensor, or a respiration sensor.

17. The stimulator of claim 15, wherein the controller is configured to deliver the programmed neural stimulation therapy with the modifiable stimulation parameters, the modifiable stimulation parameter further including at least one of a modifiable duration, a modifiable pulse width, or a modifiable frequency for the stimulation signal.

18. The stimulator of claim 15, wherein:

the controller is configured to deliver an intermittent stimulation signal to provide the programmed neural stimulation therapy, the intermittent stimulation including a train of neural stimulation pulses during a portion of a stimulation period and no neural stimulation pulses during another portion of the stimulation period;

the at least one modifiable neural stimulation schedule parameter includes at least one of a duty cycle of the stimulation period, a duration for the train of neural stimulation pulses, or a start and stop timing for the train of neural stimulation pulses; and

the controller is configured to receive the therapy feedback signal from at least one of the blood pressure sensor, the heart rate sensor, or the respiration sensor and to modify at least one of the duty cycle, the duration, or the start and stop timing for the train of neural stimulation pulses in response to the therapy feedback signal.

19. The stimulator of claim 18, wherein the neural stimulation scheduler includes a programmed limit for limiting modifications of at least one of:

the duty cycle of the stimulation period using a programmed maximum allowable duty cycle or a programmed allowable range for allowed modifications to the duty cycle of the stimulation period;

or

the duration for the train of neural stimulation pulses using a programmed minimum duration for the train of neural stimulation pulses or a programmed allowable range for allowed modifications to the duration for the train of neural stimulation pulses.

20. The stimulator of claim 18, wherein the programmed neural stimulation therapy is a programmed heart failure therapy.