DEVICE AND METHOD FOR DETECTING THE DIRECTION OF THE FLOW OF LIQUID THROUGH A DIALYZER

• US 20130193039A1
• Filed: 07/29/2011
• Published: 08/01/2013
• Est. Priority Date: 07/31/2010
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius SE & Co. KGaA)
• Inventors: Kopperschmidt, Pascal
• Granted Patent: US 9,132,224 B2
• Time in Patent Office: Days
• US Class Current: 210/87
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1617 using measurements made during a temporary variation of a characteristic of the fresh dialysis fluid
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/702 automatically during use
• CPC Class Codes: G01P 13/02 Indicating direction only, e.g. by weather vane

Abstract

The present invention relates to a device and a method for detecting the direction of the fluid flow through a dialyzer, as well as an extracorporeal blood treatment apparatus which comprises a device for detecting the direction of the fluid flow through the dialyzer. The devices and methods according to the present invention are based on the change in a physical and/or chemical property, for example the substance concentration or the temperature, of a fluid flowing into the one chamber of the dialyzer and the measurement of the change in the physical and/or chemical property of the fluid flowing out of the one chamber of the dialyzer.

Claims

1-22. -22. (canceled)

23. A device for detecting the direction of the fluid flow through a dialyzer which comprises a first chamber which has a first and second connection and a second chamber which has a first and second connection, wherein the first chamber and the second chamber are separated from one another by a semipermeable membrane, the device comprising:

a system for reversing the flow direction configured such that the dialyzer can be switched over between an equi-directional flow operation, wherein a first fluid flows into the first connection of the first chamber and the first fluid flows out of the second connection of the first chamber, while the second fluid flows into the first connection of the second chamber and the second fluid flows out of the second connection of the second chamber, and a counter-flow operation, wherein the first fluid flows into the second connection of the first chamber and the first fluid flows out of the first connection of the first chamber, while the second fluid flows into the first connection of the second chamber and the second fluid flows out of the second connection of the second chamber, or alternatively, between the counter-flow operation and the equi-directional flow operation;

a system for changing a physical and/or chemical property of the fluid flowing into the first and/or second connection of the first chamber,

a system for measuring the physical and/or chemical property of the fluid flowing out of the second and/or first connection of the first chamber, and

a computing and evaluation system cooperating with the system for measuring the physical and/or chemical property, said computing and evaluation system being configured such that, on the basis of the change in the physical and/or chemical property of the first fluid flowing out of the second and/or first connection of the first chamber, said change being measured before the reversal of the flow direction and after the reversal of the flow direction and being able to be traced back to the change in the physical and/or chemical property of the first fluid flowing into the first and/or second connection of the first chamber, it is concluded whether the dialyzer has been operated with an equi-directional flow operation or a counter-flow operation before the reversal of the flow direction.

24. The device according to claim 23, wherein the system for measuring the physical and/or chemical property is provided for measuring the physical and/or chemical property of the fluid flowing into the first and/or second connection of the first chamber.

25. The device according to claim 24, wherein the computing and evaluation system is configured such that an integral over the physical and/or chemical property of the first fluid flowing into the first connection of the first chamber and an integral of the first fluid flowing out of the second connection of the first chamber are calculated before the reversal of the flow direction and an integral over the physical and/or chemical property of the first fluid flowing into the second connection of the first chamber and an integral of the first fluid flowing out of the first connection of the first chamber are calculated after the reversal of the flow direction,

wherein the operation of the dialyzer before the reversal of the flow direction with an equi-directional flow or with a counter-flow is determined on the basis of a comparison of the difference between the two integral values after the reversal of the flow direction with the difference between the two integral values before the reversal of the flow direction.

26. The device according to claim 25, wherein the computing and evaluation system is configured such that a quotient of the difference between the two integral values after the reversal of the flow direction and a difference between the two integral values before the reversal of the flow direction is calculated,

wherein it is concluded that an operation of the dialyzer before the reversal of the flow direction is with an equi-directional flow if the quotient is greater than 1 or it is concluded that there is an operation of the dialyzer before the reversal of the flow direction with a counter-flow if the quotient is less than 1.

27. The device according to claim 23, wherein, the first fluid is dialyzing fluid.

28. The device according to claim 23, wherein the second fluid is blood.

29. The device according to claim 23, wherein the physical and/or chemical property is a concentration of a substance in the fluid, the system for measuring the physical and/or chemical property being a system for measuring the substance concentration.

30. The device according to claim 23, wherein the physical and/or chemical property is the temperature of the fluid, the system for measuring the physical and/or chemical property being a system for measuring the temperature.

31. The device according to claim 23, wherein the computing and evaluation system cooperates with an alarm system which emits an optical and/or acoustic and/or tactile alarm when the computing and evaluation system has ascertained an operation of the dialyzer with an equi-directional flow before the reversal of the flow direction.

32. The device according to claim 23, wherein the computing and evaluation system generates a control signal for an intervention into a machine control when the computing and evaluation system has ascertained an operation of the dialyzer with an equi-directional flow before the reversal of the flow direction.

33. The device according to claim 32, wherein the control signal for the intervention into the machine control is a control signal activating the system for reversing the flow direction.

34. An extracorporeal blood treatment apparatus comprising:

an extracorporeal blood circuit comprising a blood chamber of a dialyzer divided by a semi-permeable membrane into a blood chamber and a dialyzing fluid chamber, and a dialyzing fluid system which includes the dialyzing fluid chamber,

wherein the extracorporeal blood treatment apparatus comprises a device for detecting a direction of the fluid flow through a dialyzer according to claim 23.

35. A method for detecting the direction of the fluid flow through a dialyzer which comprises a first chamber which has a first and second connection and a second chamber which has a first and second connection, wherein the first chamber and the second chamber are separated from one another by a semipermeable membrane, the method comprising the steps of:

changing a physical and/or chemical property of a first fluid flowing into the first connection of the first chamber, while a second fluid flows into the first connection of the second chamber of the dialyzer and out of the second connection of the second chamber of the dialyzer,

measuring the physical and/or chemical property of the first fluid flowing out of the second connection of the first chamber, which physical and/or chemical property can be traced back to the change in the physical and/or chemical property of the first fluid flowing into the first connection of the first chamber,

reversing the flow direction such that the first fluid flows into the second connection of the first chamber and the first fluid flows out of the first connection of the first chamber, and,

concluding whether the dialyzer has been operated in an equi-directional flow operation or in a counter-flow operation before reversal of the flow direction, wherein said concluding is made on the basis of the change in the physical and/or chemical property of the first fluid flowing out of the second and/or first connection of the first chamber, said change being measured before the reversal of the flow direction and after the reversal of the flow direction and being able to be traced back to the change in the physical and/or chemical property of the first fluid flowing into the first and/or second connection of the first chamber.

36. The method according to claim 35, wherein the physical and/or chemical property of the fluid flowing into the first and/or second connection of the first chamber is measured.

37. The method according to claim 36, wherein an integral over the physical and/or chemical property of the first fluid flowing into the first connection of the first chamber and an integral of the first fluid flowing out of the second connection of the first chamber are calculated before the reversal of the flow direction, and an integral over the physical and/or chemical property of the first fluid flowing into the second connection of the first chamber and an integral of the first fluid flowing out of the first connection of the first chamber are calculated after the reversal of the flow direction,

wherein the operation of the dialyzer before the reversal of the flow direction with an equi-directional flow or with a counter-flow is determined on the basis of a comparison of a difference between the two integral values after the reversal of the flow direction with a difference between the two integral values before the reversal of the flow direction.

38. The method according to claim 37, wherein a quotient of the difference between the two integral values after the reversal of the flow direction and a difference between the two integral values before the reversal of the flow direction is calculated, wherein it is concluded that there is an operation of the dialyzer with an equi-directional flow before the reversal of the flow direction if the quotient is greater than 1 or it is concluded that there is an operation of the dialyzer with a counter-flow before the reversal of the flow direction if the quotient is less than 1.

39. The method according to claim 35, wherein the first fluid is dialyzing fluid.

40. The method according to claim 35, wherein the second fluid is blood.

41. The method according to claim 35, wherein the physical and/or chemical property is the concentration of a substance in the fluid.

42. The method according to claim 35, wherein the physical and/or chemical property is the temperature of the fluid.

43. The method according to claim 35, wherein an optical and/or acoustic and/or tactile alarm is emitted if, before the reversal of the flow direction, an operation of the dialyzer with an equi-directional flow is ascertained.

44. The method according to claim 35, wherein a control signal for an intervention into a machine control is generated if, before the reversal of the flow direction, an operation of the dialyzer with an equi-directional flow is ascertained.