Cellular Constituents From Bacteroides, Compositions Thereof, and Therapeutic Methods Employing Bacteroides or Cellular Constituents Thereof

• US 20130195802A1
• Filed: 06/01/2011
• Published: 08/01/2013
• Est. Priority Date: 06/01/2010
• Status: Abandoned Application

• Current Assignee: Moore Research Enterprises, LLC
• Original Assignee: Moore Research Enterprises, LLC
• Inventors: Moore, Brenda E.
• Application Number:
  US13/701,350
• Publication Number:
  US 20130195802A1
• Time in Patent Office: Days
• US Class Current: 424/93.2
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/32 having an effect on the health of the digestive tract
• CPC Class Codes: A23V 2250/206 Bacterial extracts
• CPC Class Codes: A61K 35/66 Microorganisms or materials therefrom fungi, yeasts or candida A61K36/06
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: C12P 1/04 by using bacteria

Abstract

A cellular constituent is lysed from, produced by and/or isolated from one or more bacteria from the genus Bacteroides, and the cellular constituent, a derivative thereof, and/or one or more bacteria from the genus Bacteroides, or a modified form thereof, is employed in compositions and methods for modulating an inflammatory response. Such methods include methods of treating, delaying the onset of or reducing the symptoms of one or more inflammatory conditions/diseases, including corporal or gastrointestinal inflammation, for example, Irritable Bowel Syndrome, Crohn'"'"'s Disease, or colitis, and/or associated diseases such diabetes, asthma, multiple sclerosis, cancer, rheumatoid arthritis, gingivitis, atopic diseases, for example, hay fever, food allergies, eczema, rhinitis, dermatitis, conjunctivitis, atopic syndrome and keratosis pelaris, ocular inflammatory disease, strokes, cardiovascular disease, depression, atherosclerosis and hypertension, and comprise administering a composition comprising one or more natural and/or modified bacteria of the genus Bacteroides, and/or a cellular constituent lysed from, produced by, or isolated from one or more natural and/or modified bacteria from the genus Bacteroides, or a derivative thereof.

Claims

1. A cellular constituent lysed from, produced by, or isolated from a bacteria from the genus Bacteroides, or a derivative of said cellular constituent.

2. A cellular constituent or derivative thereof according to claim 1, wherein the cellular constituent is from a bacteria selected from the group consisting of Bacteroides thetaiotaomicron, B. fragilis, B. vulgatis, B. distasonis, B. ovatus, B. merdae, B. uniformis, B. eggerithii, and B. caccae.

3. A cellular constituent or derivative thereof according to claim 1, comprising DNA or RNA.

4. A cellular constituent or derivative thereof according to claim 1, comprising a cell wall component selected from the group consisting of lipopolysaccharides, lipids, carbohydrates, proteins, lipoproteins, glycoproteins, and combinations thereof.

5. A cellular constituent or derivative thereof according to claim 1, comprising a product of the bacteria and selected from the group consisting of lipids, carbohydrates, proteins and genetic material.

6. A food or drink supplemented with a cellular constituent or derivative thereof according to claim 1.

7. A composition for oral administration, comprising a cellular constituent or derivative thereof according to claim 1, and a physiologically acceptable carrier.

8. A composition according to claim 7, wherein the carrier is selected from the group consisting of a capsule shell, a tableting agent and a polymer matrix.

9. A composition according to claim 7, wherein the carrier is selected from the group consisting of a capsule shell, a tableting agent, a polymer matrix, and a component providing extended release, delayed release or sustained release of the cellular constituent or derivative thereof.

10. A method of treating, delaying the onset of, or reducing the symptoms of corporal or gastrointestinal inflammation in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

11. A method for treating, delaying the onset of, or reducing the symptoms of cardiovascular disease in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

12. A method for treating, delaying the onset of, or reducing the symptoms of diabetes in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

13. A method for treating, delaying the onset of, or reducing the symptoms of colon cancer in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

14. A method for treating, delaying the onset of, or reducing the symptoms of gastrointestinal inflammation in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

15. A method according to claim 14, wherein the gastrointestinal inflammation is associated with a disease selected from the group consisting of Irritable Bowl Syndrome, Crohn'"'"'s Disease, and colitis.

16. A method for treating, delaying the onset of, or reducing the symptoms of rheumatoid arthritis in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

17. A method for treating, delaying the onset of, or reducing the symptoms of asthma in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent or derivative thereof according to claim 1.

18. A method for treating, delaying the onset of, or reducing the symptoms of multiple sclerosis in an individual, comprising administering a composition comprising a bacteria of the genus Bacteroides, or a cellular constituent according to claim 1.

19. A method according to claim 10, wherein the composition is administered in food or drink.

20. A genetically modified bacterium from the genus Bacteroides.

21. A composition for oral administration, comprising a genetically modified bacterium according to claim 20, and a physiologically acceptable carrier.

22. A synthetically derived molecule that is based upon a molecule/molecular pattern from a species within the genus Bacteroides.