USE OF GLYCOMACROPEPTIDE TO IMPROVE WOMEN'S HEALTH

• US 20130196905A1
• Filed: 01/31/2013
• Published: 08/01/2013
• Est. Priority Date: 01/31/2012
• Status: Active Grant

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Ney, Denise M., Yen, Eric Chi-Liang, Nelson, David W., Solverson, Patrick
• Granted Patent: US 9,180,168 B2
• Time in Patent Office: Days
• US Class Current: 514/4.8
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/306 having an effect on bone mass, e.g. osteoporosis prevention
• CPC Class Codes: A23V 2200/332 Promoters of weight control and weight loss
• CPC Class Codes: A23V 2250/55 Peptide, protein hydrolysate
• CPC Class Codes: A61K 38/018 from milk
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 38/22 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin A61K38/33, e.g. corticotropin A61K38/35
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031

Abstract

Methods for improving the health of a female human or non-human animal are disclosed. The methods include the step of administering to the animal compositions including an effective amount of glycomacropeptide (GMP) for effectuating the methods. Specifically, the methods can be used to increase the rate of fat metabolism or fat oxidation, decrease percentage of body fat, increase the rate of bone mineralization, increase bone mineral content, increase bone mineral density, and/or increase bone strength in the animal.

GMP-containing compositions can be used according to the disclosed methods to treat obesity and related metabolic conditions, or to treat or prevent osteoporosis, osteopenia, and other conditions related to loss of bone mineral content or bone strength.

Claims

1. A method for improving the health of a female human or non-human animal comprising administering to the animal an effective amount of a composition comprising glycomacropeptide (GMP), whereby one or more of the following occurs:

(a) the rate of fat oxidation or fat metabolism in the animal is increased;

(b) the percentage of body fat in the animal is reduced;

(c) the rate of bone mineralization in the animal is increased;

(d) the bone mineral content or bone mineral density in the animal is increased;

or

(e) the bone strength in the animal is increased.

2. The method of claim 1, wherein the female animal is human.

3. The method of claim 1, wherein the composition is administered orally.

4. The method of claim 3, wherein the composition is a food product, a nutraceutical, or a dietary supplement.

5. The method of claim 1, wherein the animal does not have phenylketonuria (PKU).

6. The method of claim 1, wherein the effective amount of the composition is such that from 0.15 to 1.0 g GMP per kg of body weight is administered to the animal per day.

7. The method of claim 1, wherein the method is used to treat one or more conditions associated with reduced fat metabolism and/or an increased percentage of body fat.

8. The method of claim 7, wherein the condition treated is obesity.

9. The method of claim 1, wherein the method is used to treat one or more conditions associated with loss of bone mineral content or bone strength.

10. The method of claim 9, wherein the condition treated is osteoporosis or osteopenia.