Analysis Apparatus, Analysis Method and Analysis System

• US 20130197847A1
• Filed: 02/01/2011
• Published: 08/01/2013
• Est. Priority Date: 02/26/2010
• Status: Active Grant

• Current Assignee: ARKRAY, Inc
• Original Assignee: ARKRAY, Inc
• Inventors: Tsukada, Masashi, Kusaka, Yasuhide
• Granted Patent: US 9,588,210 B2
• Time in Patent Office: Days
• US Class Current: 702/104
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01R 35/00 Testing or calibrating of apparatus covered by the other groups of this subclass
• CPC Class Codes: G16B 40/10 Signal processing, e.g. from mass spectrometry [MS] or from PCR
• CPC Class Codes: G16B 99/00 Subject matter not provided for in other groups of this subclass

Abstract

Provided is an analysis apparatus capable of acquiring a measurement result with high reliability that includes: a signal detection unit; a measuring unit; a first temperature detection unit; a second temperature detection unit; and a calculation unit.

Claims

1. An analysis apparatus comprising:

a signal detection unit to continuously detect signal values detected from a first sample;

a measuring unit to measure numerical value information on a specified substance in a second sample;

a first temperature detection unit to capture a first temperature value defined as temperature information on the first sample;

a second temperature detection unit to capture a second temperature value defined as temperature information on the second sample; and

a calculation unit to calibrate to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample in accordance with the first temperature value and the second temperature value.

2. The analysis apparatus according to claim 1, wherein the calculation unit, when a value calculated from the first temperature value and the second temperature value is equal to or smaller than a predetermined threshold value, calibrates to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample.

3. The analysis apparatus according to claim 1, wherein the calculation unit changes the first temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, corrects the signal value detected from the first sample on the basis of the post-changed first temperature value when a value calculated from the post-changed first temperature value and the second temperature value is equal to or smaller than the predetermined threshold value, and calibrates to the numerical value information on the specified substance in the first sample from the post-corrected signal value by referring to the numerical value information on the specified substance in the second sample.

4. The analysis apparatus according to claim 1, wherein the calculation unit changes the second temperature value when a value calculated from the first Page 9 temperature value and the second temperature value exceeds a predetermined threshold value, corrects the numerical value information on the specified substance in the second sample on the basis of the post-changed second temperature value when a value calculated from the first temperature value and the post-changed second temperature value is equal to or smaller than the predetermined threshold value, and calibrates to the numerical value information on the specified substance in the first sample from the signal value by referring to the post-corrected numerical value information on the specified substance in the second sample.

5. The analysis apparatus according to claim 1, wherein the calculation unit changes the first temperature value and the second temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, corrects the signal value detected from the first sample on the basis of the post-changed first temperature value when a value calculated from the post-changed first temperature value and the post-changed second temperature value is equal to or smaller than the predetermined threshold value, further corrects the numerical value information on the specified substance in the second sample on the basis of the post-changed second temperature value, and calibrates to the numerical value information on the specified substance in the first sample from the post-corrected signal value by referring to the post-corrected numerical value information on the specified substance in the second sample.

6. An analysis method comprising:

a signal detecting step of continuously detecting signal values detected from a first sample;

a measuring step of measuring numerical value information on a specified substance in a second sample;

a first temperature detecting step of capturing a first temperature value defined as temperature information on the first sample;

a second temperature detecting step of capturing a second temperature value defined as temperature information on the second sample; and

a calculating step of calibrating to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample in accordance with the first temperature value and the second temperature value.

7. The analysis method according to claim 6, wherein the calculating step includes, when a value calculated from the first temperature value and the second temperature value is equal to or smaller than a predetermined threshold value, calibrating to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample.

8. The analysis method according to claim 6, wherein the calculating step includes changing the first temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, correcting the signal value detected from the first sample on the basis of the post-changed first temperature value when a value calculated from the post-changed first temperature value and the second temperature value is equal to or smaller than the predetermined threshold value, and calibrating to the numerical value information on the specified substance in the first sample from the post-corrected signal value by referring to the numerical value information on the specified substance in the second sample.

9. The analysis method according to claim 6, wherein the calculating step includes changing the second temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, correcting the numerical value information on the specified substance in the second sample on the basis of the post-changed second temperature value when a value calculated from the first temperature value and the post-changed second temperature value is equal to or smaller than the predetermined threshold value, and calibrating to the numerical value information on the specified substance in the first sample from the signal value by referring to the post-corrected numerical value information on the specified substance in the second sample.

10. The analysis method according to claim 6, wherein the calculating step includes changing the first temperature value and the second temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, correcting the signal value detected from the first sample on the basis of the post-changed first temperature value when a value calculated from the post-changed first temperature value and the post-changed second temperature value is equal to or smaller than the predetermined threshold value, further correcting the numerical value information on the specified substance in the second sample on the basis of the post-changed second temperature value, and calibrating to the numerical value information on the specified substance in the first sample from the post-corrected signal value by referring to the post-corrected numerical value information on the specified substance in the second sample.

11. An analysis system comprising:

a detection device including;

a signal detection unit to continuously detect signal values detected from a first sample; and

a first temperature detection unit to capture a first temperature value defined as temperature information on the first sample;

an analysis device including;

a measuring unit to measure numerical value information on a specified substance in a second sample; and

a display device including;

a display unit to display the numerical value information on a specified substance in the first sample,

the analysis system further comprising;

a second temperature detection unit to capture a second temperature value defined as temperature information on the second sample; and

a calculation unit to calibrate to the numerical value information on the specified substance in the first sample from the signal value detected from the first sample by referring to the numerical value information on the specified substance in the second sample in accordance with the first temperature value and the second temperature value.

12. The analysis system according to claim 11, wherein the calculation unit, when a value calculated from the first temperature value and the second temperature value is equal to or smaller than a predetermined threshold value, calibrates to the numerical value information on the specified substance in the first sample from the signal value by referring to the numerical value information on the specified substance in the second sample.

13. The analysis system according to claim 11, wherein the calculation unit changes the first temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, corrects the signal value detected from the first sample on the basis of the post-changed first temperature value when a value calculated from the post-changed first temperature value and the second temperature value is equal to or smaller than the predetermined threshold value, and calibrates to the numerical value information on the specified substance in the first sample from the post-corrected signal value by referring to the numerical value information on the specified substance in the second sample.

14. The analysis system according to claim 11, wherein the calculation unit changes the second temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, corrects the numerical value information on the specified substance in the second sample on the basis of the post-changed second temperature value when a value calculated from the first temperature value and the post-changed second temperature value is equal to or smaller than the predetermined threshold value, and calibrates to the numerical value information on the specified substance in the first sample from the signal value by referring to the post-corrected numerical value information on the specified substance in the second sample.

15. The analysis system according to claim 11, wherein the calculation unit changes the first temperature value and the second temperature value when a value calculated from the first temperature value and the second temperature value exceeds a predetermined threshold value, corrects the signal value detected from the first sample on the basis of the post-changed first temperature value when a value calculated from the post-changed first temperature value and the post-changed second temperature value is equal to or smaller than the predetermined threshold value, further corrects the numerical value information on the specified substance in the second sample on the basis of the post-changed second temperature value, and calibrates to the numerical value information on the specified substance in the first sample from the post-corrected signal value by referring to the post-corrected numerical value information on the specified substance in the second sample.