COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER

• US 20130203794A1
• Filed: 10/04/2011
• Published: 08/08/2013
• Est. Priority Date: 10/20/2010
• Status: Active Grant

• Current Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Winkler, Jeffrey D., Dahmane, Nadia, Isaacs, Andre
• Granted Patent: US 8,759,367 B2
• Time in Patent Office: Days
• US Class Current: 514/278
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C07D 491/107 with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

The present invention relates to compounds for modulating sonic hedgehog signaling and preventing or treating cancer.

Claims

1. A compound having the structure:

2. The compound of claim 1, wherein said compound is AKI0532 or a compound set forth in Table 1.

3. Use of a compound of claim 1 for the manufacture of a medicament for the prevention or treatment of cancer.

4. A pharmaceutical composition comprising a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.

5. The pharmaceutical composition of claim 4, wherein said composition is formulated for parenteral, transdermal, oral, subcutaneous, intrapulmonary, topical or intranasal administration.

6. A method for inhibiting sonic hedgehog signaling in a cell comprising contacting a cell with a compound of claim 1 thereby inhibiting sonic hedgehog signaling in the cell.

7. The method of claim 6, wherein said method is carried out in vitro.

8. The method of claim 6, wherein the cell is a cancer cell.

9. A method for preventing or treating cancer comprising administering to a subject in need of treatment an effective amount of the pharmaceutical composition of claim 4 thereby preventing or treating the subject'"'"'s cancer.

10. The method of claim 9, wherein the cancer is breast cancer, prostate cancer, small cell lung cancer, lung adenocarcinoma, melanoma, pancreatic cancer, basal cell carcinoma, medulloblastoma, or meningioma.

11. The method of claim 10, wherein the cancer has metastasized.