Methods and Systems For Assessing Muscle Electrical Activity in Response to Stimulation of a Motor Nerve
First Claim
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1. A method for assessing neuromuscular blockade in a subject having been administered a muscle relaxant agent, comprising:
- stimulating a motor nerve to cause an evoked muscle response;
recording the evoked muscle response, the evoked muscle response comprising a floating differential signal;
quantifying the recorded muscle response; and
comparing the quantified muscle response to a control muscle response, wherein the comparison indicates a level of neuromuscular blockade in the subject.
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Abstract
Provided are systems, devices and methods for monitoring anesthesia. For example, the methods, devices and systems are optionally used to assess muscle electrical activity in response to stimulation of a motor nerve.
15 Citations
52 Claims
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1. A method for assessing neuromuscular blockade in a subject having been administered a muscle relaxant agent, comprising:
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stimulating a motor nerve to cause an evoked muscle response; recording the evoked muscle response, the evoked muscle response comprising a floating differential signal; quantifying the recorded muscle response; and comparing the quantified muscle response to a control muscle response, wherein the comparison indicates a level of neuromuscular blockade in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for assessing neuromuscular blockade in a subject having been administered a muscle relaxant agent, comprising:
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a stimulator configured to generate one or more stimuli for stimulating a motor nerve to cause an evoked muscle response; a patient-stimulus interface configured to supply each stimulus generated by the stimulator to the patient; a patient-recording interface configured to record the evoked muscle response in a muscle innervated by the motor nerve, the evoked muscle response comprising a floating differential signal; and at least one processing device configured to; quantify the recorded muscle response; and compare the quantified muscle response to a control muscle response, wherein the comparison indicates a level of neuromuscular blockade in the subject. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A system for assessing neuromuscular blockade in a subject having been administered a muscle relaxant agent, comprising:
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a stimulator configured to generate one or more stimuli for stimulating a motor nerve to cause an evoked muscle response; a patient-stimulus interface configured to supply each stimulus generated by the stimulator to the patient; a patient-recording interface comprising at least two recording electrodes and configured to record muscle electrical activity of a muscle innervated by the motor nerve, wherein the patient-recording interface does not include a common reference electrode; and at least one processing device configured to; quantify the recorded muscle electrical activity; and compare the quantified muscle electrical activity to a control muscle electrical activity, wherein the comparison indicates a level of neuromuscular blockade in the subject. - View Dependent Claims (16, 17, 18, 19, 20)
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21. An electrode system for use with a system for assessing neuromuscular blockade in a subject, comprising:
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one or more stimulation electrodes configured to deliver a stimulus to a motor nerve of the subject; and at least two recording electrodes configured to record muscle electrical activity of a muscle innervated by the motor nerve, wherein the electrode system does not include a common reference electrode. - View Dependent Claims (22, 23, 24)
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25. A system for assessing muscle electrical activity in a subject, comprising:
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a motor nerve stimulator configured to stimulate a targeted motor nerve of the subject; a recording apparatus for recording electrical activity of a muscle innervated by the motor nerve; and a recording apparatus for recording electrical activity of the targeted motor nerve. - View Dependent Claims (26, 27, 28, 30, 31)
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29. The system of claim 29, wherein the processing system is further configured to indicate that the nerve was not stimulated if there is no electrical response to the stimulus recorded in the nerve.
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32. A method for identifying whether a motor nerve in a subject has been stimulated, comprising:
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applying a stimulus to the subject, wherein the stimulus is targeted to stimulate the motor nerve; recording for an electrical response to the applied stimulus in the targeted motor nerve; and recording for an electrical response to the applied stimulus in a muscle innervated by the targeted motor nerve, wherein the presence or absence of an electrical response to the applied stimulus in the muscle and the presence or absence of an electrical response to the applied stimulus in the targeted motor nerve is used to assess whether the motor nerve was simulated. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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39. A method for assessing neuromuscular blockade in a subject having been administered a muscle relaxant agent, comprising:
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applying a stimulus to the subject, wherein the stimulus is targeted to stimulate a motor nerve; recording for an electrical response to the applied stimulus in the targeted motor nerve; and recording for an electrical response to the applied stimulus in a muscle innervated by the targeted motor nerve, wherein the recorded electrical response of the nerve and the recorded electrical response of the muscle are used to assess neuromuscular blockade in the subject. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47)
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48. A method for assessing neuromuscular blockage in a subject having been administered a muscle relaxant agent, comprising:
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applying a stimulus to the subject, wherein the stimulus is targeted to stimulate a motor nerve; recording for an electrical response to the stimulus in a muscle innervated by the targeted motor nerve; and recording for an electrical response to the stimulus in the targeted motor nerve, wherein an absent or diminished electrical response to the stimulus in the muscle and the presence of an electrical response to the stimulus in the motor nerve indicates neuromuscular blockade in the subject. - View Dependent Claims (49)
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50. A system for assessing muscle electrical activity in a subject, comprising:
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a motor nerve stimulator configured to stimulate a targeted motor nerve of the subject, the motor nerve stimulator comprising; a power source; and at least one stimulating electrode; and a recording apparatus for recording electrical activity of a muscle innervated by the motor nerve and for recording electrical activity of the targeted motor nerve, the recording apparatus including; a power source; and at least one recording electrode, wherein the motor nerve stimulator and the recording apparatus are in galvanic isolation. - View Dependent Claims (51, 52)
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Specification