MASS SPECTROMETER HAVING AN ION GUIDE WITH AN AXIAL FIELD

• US 20130206973A1
• Filed: 02/15/2012
• Published: 08/15/2013
• Est. Priority Date: 02/15/2012
• Status: Active Grant

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Viatcheslav V. Kovtoun
• Inventors: KOVTOUN, Viatcheslav V., Remes, Philip M., Zhuk, Yevgeniy N.
• Granted Patent: US 8,785,847 B2
• Time in Patent Office: Days
• US Class Current: 250/282
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles

Abstract

A mass spectrometer having an ion guide with an axial field is described. The ion guide includes electrodes with longitudinally extending gaps and inserts configured to be proximate to the gaps.

Claims

1. An ion guide comprising:

(a) a plurality of electrodes arranged about a device centerline to form an internal volume, at least two of the electrodes including a longitudinally extending gap, in which the longitudinally extending gap splits the electrode into two portions displaced from one another, the electrodes including an inward surface facing the device centerline to form a periphery of the internal volume;

(b) a plurality of resistive inserts configured to be proximate to at least two of the gaps and radially aligned with respect to the device centerline, the resistive inserts including an innermost surface that faces the device centerline where the innermost surface is a first distance from the periphery of the internal volume;

(c) a RF voltage supply configured to apply a RF voltage to the plurality of electrodes that establishes a RF field to radially confine ions; and

(d) a DC voltage supply configured to apply a first DC voltage to a first location of the resistive insert and a second DC voltage to a second location of the resistive insert that establishes an axial electric field gradient along at least a portion of the device centerline, in which the second DC voltage is different than the first DC voltage and the second location is longitudinally spaced apart from the first location.

2. The ion guide of claim 1, in which two of the resistive inserts are arranged in an opposing format with respect to the device centerline.

3. The ion guide of claim 1, in which two the resistive inserts are arranged so that an approximately straight line intersects the two resistive inserts and the device centerline and goes through the gaps proximate to the two respective inserts.

4. The ion guide of claim 1, in which the RF voltage supply is also configured to apply the RF voltage to the resistive inserts.

5. The ion guide of claim 1, in which the first distance is about the same at both the first and second locations of the resistive insert.

6. The ion guide of claim 1, in which the resistive inserts and the electrodes include a first length and a second length, respectively, that extend approximately parallel with the device centerline and configured so that the first length and the second length are about the same.

7. The ion guide of claim 1, in which the resistive inserts and the electrodes include a first length and a second length, respectively, that extend approximately parallel with the device centerline and configured so that the first length is less than the second length.

8. The ion guide of claim 1, in which the device centerline is approximately straight, and the plurality of electrodes and the plurality of resistive inserts both include a longitudinal axis that is approximately parallel to the device centerline.

9. The ion guide of claim 1, in which the device centerline includes a curvature, and the plurality of electrodes and the plurality of resistive inserts both include a curved longitudinal axis that corresponds to the curvature of the device centerline.

10. The ion guide of claim 1, in which the plurality of electrodes are symmetrically arranged about the device centerline.

11. The ion guide of claim 1, in which the plurality of resistive inserts are symmetrically arranged about the device centerline.

12. The ion guide of claim 1, in which the difference in the applied voltage from the first location to the second location along the device centerline ranges from about 5 V to about 50 V.

13. The ion guide of claim 1, in which the electrodes include an inward surface facing the device centerline having a shape selected from the group consisting of a curved surface from a cylinder, a flat surface, and a hyperbolic surface.

15. The ion guide of claim 1 further comprising a conduit configured to add a collision gas to the internal volume.

16. The ion guide of claim 1, in which the first distance ranges from about 0.5 millimeters to about 1.0 millimeters.

17. The ion guide of claim 1, in which the resistive insert has a resistivity ranging from about 106 to about 1010 ohms per square.

18. The ion guide of claim 1, in which the gap ranges from about 0.5 millimeters to about 1.5 millimeters.

19. The ion guide of claim 1, in which the resistive insert has a resistivity with a relative variation of less than about 10%.

20. The ion guide of claim 1, in which the resistive insert has a dissipation loss factor greater than about 0.01 at 1 MHz.

21. The ion guide of claim 1, in which the resistive inserts are proximate to and at least partially disposed within the gap.

22. The ion guide of claim 1, in which the resistive inserts comprise a plastic.

14. (canceled)

23. (canceled)

24. A mass spectrometer comprising:

(a) an ionization source configured to ionize molecules;

(b) an ion guide configured to receive the ionized molecules, the ion guide comprising;

(i) a plurality of electrodes arranged about a device centerline to form an internal volume, at least two of the electrodes including a longitudinally extending gap, in which the longitudinally extending gap splits the electrode into two portions displaced from one another, the electrodes including an inward surface facing the device centerline to form a periphery of the internal volume;

(ii) a plurality of resistive inserts configured to be proximate to at least two of the gaps and radially aligned with respect to the device centerline, the resistive inserts including an innermost surface that faces the device centerline where the innermost surface is a first distance from the periphery of the internal volume;

(iii) a RF voltage supply configured to apply a RF voltage to the plurality of electrodes that establishes a RF field to radially confine ions; and

(iv) a DC voltage supply configured to apply a first DC voltage to a first location of the resistive insert and a second DC voltage to a second location of the resistive insert that establishes an axial electric field gradient along at least a portion of the device centerline, in which the second DC voltage is different than the first DC voltage and the second location is longitudinally spaced apart from the first location.

(c) a mass analyzer configured to receive the ionized molecules from the ion guide and filter the ionized molecules so that a subset of ionized molecules having a particular mass to charge ratio passes through; and

(d) a detector configured to receive and measure the ionized molecules from the mass analyzer.

25. An ion guide comprising:

(a) a plurality of electrodes arranged about a device centerline to form an internal volume, the internal volume including a front end configured to allow ions to enter and a back end configured to allow ions to exit, where at least two of the electrodes including a longitudinally extending gap, in which the longitudinally extending gap splits the electrode into two portions displaced from one another, the electrodes including an inward surface facing the device centerline to form a periphery of the internal volume;

(b) a plurality of conductive inserts configured to be proximate to at least two of the gaps, the conductive inserts including an innermost surface that faces the device centerline where the innermost surface includes

(i) a first distance from the periphery of the internal volume at the front end, and

(ii) a second distance from the periphery of the internal volume at the back end,

the first distance being greater than the second distance;

(c) a RF voltage supply configured to apply a RF voltage to the plurality of electrodes that establishes a RF field to radially confine ions; and

(d) a DC voltage supply configured to apply a DC voltage to the conductive inserts that establishes an axial electric field gradient to move ions along the device centerline.

26. The ion guide of claim 25, in which the RF voltage supply is also configured to apply the RF voltage to the conductive inserts.

27. A method of guiding ions in a mass spectrometer, the method comprising:

(a) injecting ions into an ion guide, the ion guide comprising;

(i) a plurality of electrodes arranged about a device centerline to form an internal volume, the internal volume including a front end configured to allow ions to enter and a back end configured to allow ions to exit, where at least two of the electrodes including a longitudinally extending gap, in which the longitudinally extending gap splits the electrode into two portions displaced from one another;

(ii) a plurality of inserts configured to be proximate to at least two of the gaps, the inserts including an innermost surface that faces the device centerline where the innermost surface includes a first distance from the device centerline;

(b) applying a RF voltage to the plurality of electrodes that establishes a RF field to radially confine ions; and

(c) applying at least one DC voltage to the plurality of inserts that establishes an axial electric field gradient along at least a portion of the device centerline.

28. The method of claim 27 further comprising:

(d) measuring a detection current at a detector configured to receive ions from the ion guide so that the detection current achieves a steady-state value within 1 milliseconds or less.