Implantable Biosensor Device and Methods of Use Thereof
First Claim
1. A sensor device for detecting the presence or concentration of an analyte in a fluid comprising:
- a structural body which comprises a first reservoir that has a first opening in the structural body;
a working electrode located within the first reservoir;
a catalyst covering at least a portion of the working electrode;
an oxygen-generating auxiliary electrode located within the first reservoir; and
at least one reservoir cap closing the first opening to isolate the working electrode and the auxiliary electrode within the first reservoir and to prevent an analyte outside of the first reservoir from contacting the catalyst.
2 Assignments
0 Petitions
Accused Products
Abstract
Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir, a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.
24 Citations
31 Claims
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1. A sensor device for detecting the presence or concentration of an analyte in a fluid comprising:
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a structural body which comprises a first reservoir that has a first opening in the structural body; a working electrode located within the first reservoir; a catalyst covering at least a portion of the working electrode; an oxygen-generating auxiliary electrode located within the first reservoir; and at least one reservoir cap closing the first opening to isolate the working electrode and the auxiliary electrode within the first reservoir and to prevent an analyte outside of the first reservoir from contacting the catalyst. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for in vivo monitoring of a patient'"'"'s glucose level, comprising:
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implanting in the patient a device which comprises an array of two or more reservoirs, each reservoir having at least one opening closed off by a reservoir cap and each reservoir containing a working electrode, a membrane and glucose oxidase covering at least a portion of the working electrode, and an oxygen-generating auxiliary electrode; disintegrating the reservoir cap of a first of the two or more reservoirs to permit glucose to enter the first reservoir; generating oxygen using the oxygen-generating auxiliary electrode of the first reservoir; and using the working electrode of the first reservoir to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of the glucose oxidase, and thereby to detect the level of endogenous glucose in the patient. - View Dependent Claims (28, 29, 30, 31)
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Specification