CONTROL OF BIOFOULING IN IMPLANTABLE BIOSENSORS
First Claim
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1. A device comprising:
- a biosensor having disposed upon it a coating;
the coating comprising;
a polymer matrix;
where the polymer matrix is operative to facilitate an inwards and outwards diffusion of analytes, byproducts and other water soluble entities towards a sensing element of the biosensor; and
a sacrificial moiety;
the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.
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Abstract
Disclosed herein is a device comprising a biosensor having disposed upon it a coating; the coating comprising a polymer matrix; where the polymer matrix is operative to facilitate the inwards and outwards diffusion of analytes and byproducts to and from the sensing element of the biosensor; and a sacrificial moiety; the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.
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Citations
25 Claims
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1. A device comprising:
a biosensor having disposed upon it a coating;
the coating comprising;a polymer matrix;
where the polymer matrix is operative to facilitate an inwards and outwards diffusion of analytes, byproducts and other water soluble entities towards a sensing element of the biosensor; anda sacrificial moiety;
the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of manufacturing a biosensor comprising:
disposing a coating on a biosensor;
the coating comprising;a polymer matrix;
where the polymer matrix is operative to facilitate an inwards and outwards diffusion of analytes and byproducts to and from the sensing element of the biosensor; anda sacrificial moiety;
the sacrificial moiety being dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.
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21. An analyte-sensing device capable of reliable sensing in a biofouling-prone media comprising:
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a sensing element; a self sealing layer disposed on the sensing element capable of allowing diffusion of electro-active species towards the sensing element;
where the self sealing layer is not prone to swelling and is intimately bonded to the sensing element;one or more layers comprising enzymes that are disposed upon the self-sealing layer;
selectively the enzymes being operative to convert an analyte of interest to an electro-active species;
where the electro-active species diffuses through the self sealing layer to produce a detectable signal proportional to a concentration of the analyte;a second layer disposed upon the one or more layers that comprises enzymes;
the second layer being operative to limit diffusion of the analyte and control diffusion towards the sensor of molecules with size larger than that of the analyte;a third layer comprising a composite coating that comprises a polymer matrix and a sacrificial moiety;
where the polymer matrix is operative to facilitate the inwards and outwards diffusion of analytes and byproducts to and from the sensing element; and
wherein the sacrificial moiety is dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling. - View Dependent Claims (22, 23, 24)
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25. A method to realize an internal self-calibration of an implantable biosensor, the biosensor comprising:
two sensing elements;
where self calibration of the biosensor is achieved through differential measurement of background currents obtained from the two sensing elements;
where one of the sensing elements is encased in an outer composite membrane, while the other of the said sensing element is intentionally left blank;
the said outer composite membrane comprises a polymer matrix and a sacrificial moiety;
where the polymer matrix is operative to facilitate an inwards diffusion of analytes towards the sensing element; and
wherein the sacrificial moiety is dispersed in the polymer matrix, where the sacrificial moiety erodes with time and increases the porosity of the polymer matrix thus offsetting decreases in analyte permeability as a result of biofouling.
Specification