PREDICTION, VISUALIZATION, AND CONTROL OF DRUG DELIVERY BY INFUSION PUMPS

• US 20130218080A1
• Filed: 05/24/2011
• Published: 08/22/2013
• Est. Priority Date: 05/25/2010
• Status: Abandoned Application

• Current Assignee: Mark A. Lovich, Steward St. Elizabeth'S Medical Center Of Boston, Inc. (Steward Health Care Holdings LLC)
• Original Assignee: Mark A. Lovich
• Inventors: Sims, Nathaniel M., Peterfreund, Robert A., Parker, Michael, Lovich, Mark A.
• Application Number:
  US13/698,110
• Publication Number:
  US 20130218080A1
• Time in Patent Office: Days
• US Class Current: 604/151
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/168 Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body flow control in general G05D7/00
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: G05D 11/132 by controlling the flow of the individual components G05D11/133 takes precedence
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 70/40 relating to drugs, e.g. their side effects or intended usage

Abstract

Systems for predicting a drug delivery profile as described herein include at least one drug pump that produces a drug flow. The drug pump dispenses at least a first drug. The system also includes at least one carrier fluid pump that produces a carrier fluid flow, a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow, and a fluid path for carrying the mixed flow between the flow junction structure and a delivery point. The system further includes a processing device configured to predict the drug delivery profile at the delivery point based on determining a predicted time variation of drug concentration at the delivery point using at least a model of the mixed flow. The model includes a plurality of parameters related to propagation of the mixed flow through the fluid path.

Claims

1. A system for predicting a drug delivery profile, the system comprising:

at least one drug pump that produces a drug flow, the at least one drug pump dispensing at least a first drug;

at least one carrier fluid pump that produces a carrier fluid flow;

a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow;

a fluid path for carrying the mixed flow between the flow junction structure and a delivery point; and

a processing device configured to predict the drug delivery profile at the delivery point based on determining a predicted time variation of drug concentration at the delivery point using at least a model of the mixed flow, wherein the model includes a plurality of parameters related to propagation of the mixed flow through the fluid path.

2. The system of claim 1, further comprising a control module configured to control the drug flow and the carrier fluid flow such that a particular drug delivery profile is achieved at a future time point.

3. The system of claim 2, wherein the control module is further configured to compute a rate of the drug flow and a rate of the carrier fluid flow at a given time point such that the particular drug delivery profile is achieved at the future time point.

4. The system of claim 1, further comprising a display device for displaying data on the predicted drug delivery profile.

5. The system of claim 1, further comprising at least one alarm configured to be triggered on detecting that at least one of i) a current drug flow rate, ii) a current carrier fluid rate or iii) a predicted drug delivery profile is outside a corresponding pre-defined desired or safe range associated with the drug.

6. The system of claim 5, wherein the safe range associated with the drug is retrieved from a database.

7. The system of claim 1, further comprising at least one sensor configured to provide data on a flow rate of the mixed flow at a particular portion of the fluid path.

8. The system of claim 2, wherein the control module is configured to control the drug flow and the carrier fluid flow such that a proportion of the drug and the carrier fluid in the mixed flow, over a given portion of the fluid path, is substantially fixed.

9. The system of claim 1, wherein the processing device is further configured to predict the drug delivery profile at the delivery point based also on user-input parameters on the drug flow and the carrier flow.

10. The system of claim 1, wherein the parameters related to propagation of the mixed flow through the fluid path includes parameters characterizing one or more of i) radial diffusion, ii) axial diffusion, iii) laminar flow through the fluid path or iv) a physical or chemical property of the drug.

11. The system of claim 1, wherein the model includes structural parameters representing characteristics of at least one of the drug pump, the carrier fluid pump, the flow junction structure, or the fluid path.

12. The system of claim 11, wherein the structural parameters include a dead volume associated with the fluid path.

13. The system of claim 12, wherein the dead volume is empirically determined by examining a series of candidate empirical dead volumes and selecting one that best fits a control curve in a least squares sense.

14. The system of claim 11, wherein the processing device is further configured to access a storage device that stores the structural parameters.

15. The system of claim 1, wherein the processing device is configured to identify at least one of the drug pump, the carrier fluid pump, the flow junction structure, and the fluid path based on an identifier.

16. The system of claim 15, wherein the identifier is a radio frequency identification (RFID) tag or a barcode and the processing device is coupled to an RFID tag reader or a barcode reader.

17. The system of claim 2, further comprising at least one additional drug pump that dispenses at least a second drug and the control module is configured to control a flow of the second drug such that a particular delivery profile of the second drug is achieved at the future time point.

18. The system of claim 1, wherein at least one of the drug pump or the carrier fluid pump is a syringe pump or an infusion pump.

19. The system of claim 17, further comprising a display device for displaying data on predicted drug delivery profiles of the first and second drugs.

20-32. -32. (canceled)