BISMUTH-THIOLS AS ANTISEPTICS FOR AGRICULTURAL, INDUSTRIAL AND OTHER USES
First Claim
1. A method for protecting a plant against a bacterial, fungal or viral pathogen, comprising:
- contacting the plant with an effective amount of a bismuth-thiol (BT) composition under conditions and for a time sufficient for one or more of;
(i) prevention of infection of the plant by the bacterial, fungal or viral pathogen,(ii) inhibition of cell viability or cell growth of substantially all planktonic cells of the bacterial, fungal or viral pathogen,(iii) inhibition of biofilm formation by the bacterial, fungal or viral pathogen, and(iv) inhibition of biofilm viability or biofilm growth of substantially all biofilm-form cells of the bacterial, fungal or viral pathogen,wherein the BT composition comprises a substantially monodisperse suspension of microparticles that comprise a BT compound, said microparticles having a volumetric mean diameter of from about 0.4 μ
m to about 10 μ
m.
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Accused Products
Abstract
Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural and artificial surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
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Citations
35 Claims
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1. A method for protecting a plant against a bacterial, fungal or viral pathogen, comprising:
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contacting the plant with an effective amount of a bismuth-thiol (BT) composition under conditions and for a time sufficient for one or more of; (i) prevention of infection of the plant by the bacterial, fungal or viral pathogen, (ii) inhibition of cell viability or cell growth of substantially all planktonic cells of the bacterial, fungal or viral pathogen, (iii) inhibition of biofilm formation by the bacterial, fungal or viral pathogen, and (iv) inhibition of biofilm viability or biofilm growth of substantially all biofilm-form cells of the bacterial, fungal or viral pathogen, wherein the BT composition comprises a substantially monodisperse suspension of microparticles that comprise a BT compound, said microparticles having a volumetric mean diameter of from about 0.4 μ
m to about 10 μ
m. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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21. A method for overcoming antibiotic resistance in a plant in or on which an antibiotic-resistant bacterial plant pathogen is present, comprising
(a) contacting the plant with an effective amount of a BT composition under conditions and for a time sufficient for one or more of: -
(i) prevention of infection of the plant by the antibiotic-resistant bacterial pathogen, (ii) inhibition of cell viability or cell growth of substantially all planktonic cells of the antibiotic-resistant bacterial pathogen, (iii) inhibition of biofilm formation by the antibiotic-resistant bacterial pathogen, and (iv) inhibition of biofilm viability or biofilm growth of substantially all biofilm-form cells of the antibiotic-resistant bacterial pathogen, wherein the BT composition comprises a substantially monodisperse suspension of microparticles that comprise a BT compound, said microparticles having a volumetric mean diameter of from about 0.5 μ
m to about 10 μ
m; and(b) contacting the plant with a synergizing or enhancing antibiotic, simultaneously or sequentially and in any order with respect to the step of contacting the plant with the BT composition.
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31. A method for overcoming antibiotic resistance in or on a plant where an antibiotic-resistant bacterial pathogen is present, comprising:
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contacting the plant simultaneously or sequentially and in any order with an effective amount of (1) at least one bismuth-thiol (BT) composition and (2) at least one antibiotic that is capable of enhancing or acting synergistically with the at least one BT composition, under conditions and for a time sufficient for one or more of; (i) prevention of infection of the plant by the bacterial pathogen, (ii) inhibition of cell viability or cell growth of substantially all planktonic cells of the bacterial pathogen, (iii) inhibition of biofilm formation by the bacterial pathogen, and (iv) inhibition of biofilm viability or biofilm growth of substantially all biofilm-form cells of the bacterial pathogen, wherein the BT composition comprises a plurality of microparticles that comprise a bismuth-thiol (BT) compound, substantially all of said microparticles having a volumetric mean diameter of from about 0.4 μ
m to about 5 μ
m; and
thereby overcoming antibiotic resistance on the epithelial tissue surface. - View Dependent Claims (32, 33, 34, 35)
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Specification