Oral Care Composition Comprising Arginine and Calcium Carbonate

• US 20130224270A1
• Filed: 10/27/2010
• Published: 08/29/2013
• Est. Priority Date: 10/27/2010
• Status: Abandoned Application

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Robinson, Richard, Simon, Eric
• Application Number:
  US13/881,516
• Publication Number:
  US 20130224270A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/59 Mixtures
• CPC Class Codes: A61K 2800/592 Mixtures of compounds complementing their respective functions
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, and an abrasive system comprising natural calcium carbonate and precipitated calcium carbonate; and to methods of using and of making these compositions.

Claims

1. A dentifrice composition comprising

a. an effective amount of a basic amino acid in free or salt form;

b. an abrasive comprising

i. natural calcium carbonate (NCC) having an average particle size of 3-7 microns; and

ii. precipitated calcium carbonate (PCC);

wherein the composition has a Pellicle Cleaning Ratio (PCR), of at least 70, and a Radioactive Dentine Abrasivity (RDA) value of less than 140 and the ratio of natural calcium carbonate to precipitated calcium carbonate is from 1;

1 to 1;

5.

2. The composition according to claim 1 having precipitated calcium carbonate (PCC) having an average particle size of 1-5 microns.

4. The composition according to claim 1, further comprising an effective amount of a fluoride source.

5. The composition according to claim 1, wherein the basic amino acid in free or salt form is arginine bicarbonate.

6. The composition according to claim 1, wherein the basic amino acid is present in an amount corresponding to 1% to 15% of the total composition weight, the weight of the basic amino acid being calculated as free base form.

8. The composition according to claim 1 wherein the ratio of natural calcium carbonate to precipitated calcium carbonate is from 1:

2 to 1;

3.

9. The composition according to claim 1, wherein the natural calcium carbonate is present in an amount of 5%-20% by weight of the composition and the precipitated calcium carbonate is present in an amount of 10% to 35% by weight of the composition.

11. The composition according to claim 9, wherein the natural calcium carbonate is present in an amount of about 10% and the precipitated calcium carbonate is present in an amount of about 25% by weight of the composition.

12. The composition according to claim 1, further comprising an anionic surfactant.

13. The composition according to claim 1, further comprising an antibacterial agent.

14. The composition according to claim 1, further comprising an anionic polymer.

15. The composition according to claim 1, in the form of a toothpaste further comprising one or more of water, abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, humectants, thickeners, antimicrobial agents, preservatives, flavorings, colorings and/or combinations thereof.

16. The composition according to claim 1, wherein the precipitated calcium carbonate (PCC) has a water absorption of greater than 25 g/100 g.

17. The composition according to claim 1, comprising the following ingredients:

18. A method comprising applying an effective amount of the oral care composition of claim 1 to the oral cavity of a subject in need thereof, to

a. reduce or inhibit formation of dental caries,

b. reduce, repair or inhibit pre-carious lesions of the enamel,

c. reduce or inhibit demineralization and promote remineralization of the teeth,

d. reduce hypersensitivity of the teeth,

e. reduce or inhibit gingivitis,

f. promote healing of sores or cuts in the mouth,

g. reduce levels of acid producing bacteria,

h. to increase relative levels of arginolytic bacteria,

i. inhibit microbial biofilm formation in the oral cavity,

j. raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge,

k. reduce plaque accumulation,

l. treat, reduce, relieve or alleviate dry mouth,

m. whiten teeth,

n. reduce erosion,

o. promote systemic health,

p. immunize teeth against cariogenic bacteria;

and/or

q. clean teeth and oral cavity.

20. The composition according to claim 1, wherein the basic amino acid in free or salt form is arginine bicarbonate and is present in an amount corresponding to 1% to 15% of the total composition weight, the weight of the arginine bicarbonate being calculated as free base form and the ratio of natural calcium carbonate to precipitated calcium carbonate is from 1:

2 to 1;

3.

21. The composition according to claim 1, wherein the basic amino acid in free or salt form is arginine bicarbonate, the natural calcium carbonate is present in an amount of 5%-20% by weight of the composition, the precipitated calcium carbonate is present in an amount of 10% to 35% by weight of the composition and the ratio of natural calcium carbonate to precipitated calcium carbonate is from 1:

2 to 1;

3.

22. The composition according to claim 20, further comprising an effective amount of a fluoride source.

23. The composition according to claim 21, further comprising an effective amount of a fluoride source.

3. (canceled)

7. (canceled)

10. (canceled)

19. (canceled)