Gated Voltammetry Devices
First Claim
1. A handheld measuring device, for determining the concentration of an analyte in a sample, wherethe device is adapted to receive a sensor strip and the device comprises:
- at least two contacts;
at least one display; and
electrical circuitry establishing electrical communication between the at least two contacts and the at least one display, where the electrical circuitry includes a processor in electrical communication with an electric charger and a computer readable storage medium,where the processor is configured to implement a pulse sequence from the electric charger to the at least two contacts, where the pulse sequence comprises at least two duty cycles,where each of the duty cycles includes an excitation and a relaxation,where the relaxation is from 0.1 to 3 seconds and includes a current reduction to at least one-half the current flow at the excitation maxima,where the excitation includes a potential varied with time,where the processor is configured to measure resulting currents at the at least two contacts from at least one of the excitations including the potential varied with time, andwhere the processor is configured to determine the analyte concentration in the sample in response to the at least one of the resulting currents.
2 Assignments
0 Petitions
Accused Products
Abstract
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.
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Citations
65 Claims
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1. A handheld measuring device, for determining the concentration of an analyte in a sample, where
the device is adapted to receive a sensor strip and the device comprises: -
at least two contacts; at least one display; and electrical circuitry establishing electrical communication between the at least two contacts and the at least one display, where the electrical circuitry includes a processor in electrical communication with an electric charger and a computer readable storage medium, where the processor is configured to implement a pulse sequence from the electric charger to the at least two contacts, where the pulse sequence comprises at least two duty cycles, where each of the duty cycles includes an excitation and a relaxation, where the relaxation is from 0.1 to 3 seconds and includes a current reduction to at least one-half the current flow at the excitation maxima, where the excitation includes a potential varied with time, where the processor is configured to measure resulting currents at the at least two contacts from at least one of the excitations including the potential varied with time, and where the processor is configured to determine the analyte concentration in the sample in response to the at least one of the resulting currents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of determining a duration of a pulse sequence for determining the concentration of glucose in a blood sample, where the pulse sequence includes at least three duty cycles and each of the at least three duty cycles includes an excitation, the method comprising:
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determining a plurality of calibration sets from currents recorded during the at least three duty cycles; and determining the duration of the pulse sequence in response to a glucose concentration determined from the at least three duty cycles, where when the glucose concentration determined from the at least three duty cycles indicates a high glucose concentration, the duration of the pulse sequence is shorter than when the glucose concentration determined from the at least three duty cycles indicates a glucose concentration less than or equal to the high glucose concentration.
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30-34. -34. (canceled)
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35. A method of signaling a user to add additional sample to a sensor strip, the sensor strip including at least two electrodes, the method comprising:
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applying a gated voltammetric pulse sequence to the sample through the at least two electrodes of the sensor strip, the pulse sequence having at least two duty cycles, where each of the at least two duty cycles includes an excitation and a relaxation, and where the excitations of the at least two duty cycles include a potential varied with time; determining if the sensor strip is under-filled by comparing at least one current value recorded from the gated voltammetric pulse sequence including the at least two duty cycles to a pre-selected value; and signaling the user to add additional sample to the sensor strip if the sensor strip is under-filled.
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36-43. -43. (canceled)
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44. A voltammetric method for determining a concentration of an analyte in a sample, the voltammetric method comprising:
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applying a pulse sequence to the sample, the pulse sequence comprising at least two duty cycles having excitation/relaxation time ratios from 0.3 to 0.2; measuring resulting currents from the at least two duty cycles; and determining the concentration of the analyte in the sample from the resulting currents.
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45-51. -51. (canceled)
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52. A voltammetric method for determining a hematocrit concentration of a blood sample, the voltammetric method comprising:
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applying a gated voltammetric pulse sequence to the blood sample, the pulse sequence having at least two duty cycles, where each of the at least two duty cycles includes an excitation and a relaxation, and where the excitations of the at least two duty cycles include a potential varied with time; measuring resulting currents from at least one of the excitations; applying a semi-integral data treatment to the resulting currents, the semi-integral data treatment providing a peak portion; and quantitatively relating the peak portion to the hematocrit concentration of the blood sample.
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53-57. -57. (canceled)
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58. A voltammetric method for determining a percent hematocrit of a blood sample, the voltammetric method comprising:
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applying a gated voltammetric pulse sequence to the blood sample, the pulse sequence having at least two duty cycles, where each of the at least two duty cycles includes an excitation and a relaxation, and where the excitations of the at least two duty cycles include a potential varied with time; measuring resulting currents from at least one of the excitations; applying a derivative data treatment to the resulting currents, the derivative data treatment providing a negative derivative peak and a positive derivative peak; determining a ratio of the negative derivative peak to the positive derivative peak; and quantitatively relating the ratio to the percent hematocrit in the blood sample.
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59-63. -63. (canceled)
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64. A method of determining an amount of active ionizing agent available to react with an analyte, the method comprising:
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applying a gated voltammetric pulse sequence to a sample in a sensor strip through at least two electrodes, the pulse sequence having at least two duty cycles, the sample including an analyte and active ionizing agent, where each of the at least two duty cycles includes an excitation and a relaxation, and where the excitations of the at least two duty cycles include a potential varied with time and the excitations include forward and reverse scans; measuring resulting currents from the forward and the reverse scans of at least one of the excitations; determining a ratio of the resulting currents from the forward and the reverse scans; comparing the determined ratio to a previously determined correlation ratio and a percent active ionizing agent; and determining the amount of the active ionizing agent available to react with the analyte.
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65-71. -71. (canceled)
Specification