FLUORESCENCE SENSOR

• US 20130234042A1
• Filed: 04/24/2013
• Published: 09/12/2013
• Est. Priority Date: 10/25/2010
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Olympus Corporation, Terumo Kabushiki Kaisha
• Inventors: OTA, Ryo, SHIMIZU, Etsuro
• Granted Patent: US 8,853,649 B2
• Time in Patent Office: Days
• US Class Current: 250/458.1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator

Abstract

A fluorescence sensor includes a detection substrate section, on a first principal plane of which a concave portion having a bottom surface parallel to the first principal plane is present and, on a side surface of the concave portion of which a PD element configured to receive fluorescent light and output a detection signal is formed, an LED element disposed on the bottom surface of the concave portion of the detection substrate section and configured to generate excitation light, and an indicator layer disposed on an inside of the concave portion on the LED element and configured to generate the fluorescent light corresponding to the excitation light and an analyte amount.

Claims

1. A fluorescence sensor comprising:

a detection substrate section, on a first principal plane of which a concave portion having a bottom surface parallel to the first principal plane is present and, in at least a part of a side surface of the concave portion of which a photoelectric conversion element configured to receive fluorescent light and output a detection signal is formed;

a light-emitting element disposed on the bottom surface of the concave portion of the detection substrate section and configured to generate excitation light; and

an indicator layer disposed on an inside of the concave portion on an upper side of the light-emitting element and configured to generate the fluorescent light corresponding to the excitation light and an analyte amount.

2. The fluorescence sensor according to claim 1, wherein

the detection substrate section includes a wiring substrate and a frame-like substrate bonded to the wiring substrate, the frame-like substrate forming a through-hole to be the concave portion, and

a surface of the wiring substrate is the bottom surface of the concave portion, and a wall surface of the through-hole in the frame-like substrate is the side surface of the concave portion.

3. The fluorescence sensor according to claim 2, wherein a filter configured to transmit the fluorescent light and cut the excitation light is formed to cover a light-receiving surface of the photoelectric conversion element.

4. The fluorescence sensor according to claim 3, further comprising a long-wavelength cut filter configured to cut a long-wavelength component of the excitation light generated by the light-emitting element.

5. The fluorescence sensor according to claim 4, wherein the fluorescence sensor is a needle-type sensor including a connector section configured to fit with a fitting section of a main body section arranged outside of a body, the needle-type sensor measuring an analyte in the body.

6. The fluorescence sensor according to claim 3, wherein a second photoelectric conversion element configured to receive the fluorescent light and output a second detection signal is formed in at least a part of the bottom surface of the concave portion.

7. The fluorescence sensor according to claim 6, wherein respective center portions of the second photoelectric conversion element, the light-emitting element, and the indicator layer are formed in a same region in the concave portion.

8. The fluorescence sensor according to claim 7, further comprising a wire configured to output an aggregated detection signal of the detection signal of the photoelectric conversion element and the second detection signal of the second photoelectric conversion element.

9. The fluorescence sensor according to claim 1, wherein the concave portion is a concave portion formed in the detection substrate section composed of a semiconductor substrate.

10. The fluorescence sensor according to claim 9, wherein an opening of the concave portion is wider than the bottom surface, and the side surface is formed in a tapered shape.

11. The fluorescence sensor according to claim 10, wherein a filter configured to transmit the fluorescent light and cut the excitation light is formed to cover a light-receiving surface of the photoelectric conversion element.

12. The fluorescence sensor according to claim 11, further comprising a long-wavelength cut filter configured to cut a long-wavelength component of the excitation light generated by the light-emitting element.

13. The fluorescence sensor according to claim 12, wherein the fluorescence sensor is a needle-type sensor including a connector section configured to fit with a fitting section of a main body section arranged outside of a body, the needle-type sensor measuring an analyte in the body.

14. The fluorescence sensor according to claim 11, wherein a second photoelectric conversion element configured to receive the fluorescent light and output a second detection signal is formed in at least a part of the bottom surface of the concave portion.

15. The fluorescence sensor according to claim 14, wherein the photoelectric conversion element and the second photoelectric conversion element are simultaneously integrally formed on the side surface and the bottom surface of the concave portion.

16. The fluorescence sensor according to claim 15, wherein respective center portions of the second photoelectric conversion element, the light-emitting element, and the indicator layer are formed in a same region in the concave portion.

17. The fluorescence sensor according to claim 14, further comprising a wire configured to output an aggregated detection signal of the detection signal of the photoelectric conversion element and the second detection signal of the second photoelectric conversion element.