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SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID

  • US 20130237559A1
  • Filed: 06/29/2011
  • Published: 09/12/2013
  • Est. Priority Date: 06/30/2010
  • Status: Abandoned Application
First Claim
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1. A sustained-release oral pharmaceutical composition comprising within a single dosage form:

  • a hydrophilic matrix;

    a pharmacologically active amine-containing compound; and

    a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound;

    wherein the amine-containing compound and the salt of the cyclic organic acid are within the hydrophilic matrix; and

    wherein the composition exhibits a release profile of the amine-containing compound comprising a substantial portion that is representative of zero-order release kinetics under in vitro conditions.

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