System and Method for Generating Invasively Hyperpolarized Images

• US 20130237803A1
• Filed: 11/16/2011
• Published: 09/12/2013
• Est. Priority Date: 11/16/2010
• Status: Abandoned Application

• Current Assignee: Aspect Imaging Ltd.
• Original Assignee: Aspect Imaging Ltd.
• Inventors: Rapoport, Uri
• Application Number:
  US13/883,864
• Publication Number:
  US 20130237803A1
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 8/40 Positioning of patients, e.g. means for holding or immobilising parts of the patient's body
• CPC Class Codes: G01R 33/282 Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
• CPC Class Codes: G01R 33/54 Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Abstract

The present invention includes a system and method for generating images of at least one unhyperpolarized portion of a specimen by indirectly hyperpolarizing the at least one portion by irradiating the unhyperpolarized portion by radiation emitted from the de-excitation of excited nuclei of a hyperpolarized substance. The hyperpolarized substance is located in proximity to the specimen. Typically, the images are generated by an MRI/NMR device.

Claims

1-30. -30. (canceled)

31. An indirect-hyperpolarization system comprising:

a fluidly-sealable inner chamber accommodating a specimen said specimen comprises at least one unhyperpolarized portion of a plurality of unhyperpolarized portions of at least one region of interest, and

a fluidly-sealable outer chamber encompassing said fluidly-sealable inner chamber and comprising a hyperpolarized substance,

wherein said specimen is fluidly-isolated from said hyperpolarized substance and said hyperpolarized substance hyperpolarizes said at least one unhyperpolarized portion by electromagnetically coupling said hyperpolarized substance and said at least one unhyperpolarized portion.

32. The indirect-hyperpolarization system according to claim 31, further comprising an imaging device for generating a plurality of images of said at least one hyperpolarized portion of said specimen said imaging device is selected from the group consisting of an MRI imaging device, an NMR device, a CT imaging device, an X-ray imaging device, an ultrasound imaging device, a fluorescence imaging device, a thermal imaging device and any combination thereof.

33. The indirect-hyperpolarization system according to claim 32, wherein said imaging device further detects the presence of said at least one hyperpolarized portion and generates at least one anatomically clear image of said at least one hyperpolarized portion.

34. The indirect-hyperpolarization system according to claim 31, wherein at least one of the following is being held true (a) said hyperpolarized substance comprises water;

(b) said at least one unhyperpolarized portion comprises body fats;

(c) said at least one hyperpolarized portion comprises body fats;

further wherein said specimen is selected from the group consisting of a mammal specimen, a human specimen, a premature neonate, a reptile specimen, an amphibian specimen, a rodent specimen, a biological specimen, a biological organ, an amphibian, in vivo biological tissue, in vivo biological tissue organ, ex vivo biological tissue, ex vivo biological organ and any combination thereof; and

any combination thereof.

35. The indirect-hyperpolarization system according to claim 31, wherein said electromagnetic coupling is generated by electromagnetic signals generated by an electromagnetic signal generator;

further wherein said electromagnetic signal generator comprises an RF signal generator generating RF signals.

36. An indirect-hyperpolarization system comprising:

a fluidly-sealable inner chamber accommodating a specimen said specimen comprises at least one unhyperpolarized portion of a plurality of unhyperpolarized portions of at least one region of interest;

a fluidly-sealable outer chamber encompassing said fluidly-sealable inner chamber and comprising a hyperpolarized substance, and

an RF signal generator for exciting nuclei of said hyperpolarized substance, wherein said specimen is fluidly-isolated from said hyperpolarized substance and said at least one unhyperpolarized portion is hyperpolarized by electromagnetic signals emitted by de-excited said nuclei such that an imaging device is enabled to detect the presence of said at least one hyperpolarized portion.

37. The indirect-hyperpolarization system according to claim 36, wherein at least one of the following is held true (a) said electromagnetic signals have a wavelength within the RF spectrum;

(b) said imaging device is selected from the group consisting of an MRI device, an NMR device, a CT device, an X-ray device, an ultrasound device, a fluorescence device, a thermographic device and any combination thereof;

further wherein said imaging device further generates at least one anatomically clear image of said at least one hyperpolarized portion; and

any combination thereof.

38. The indirect-hyperpolarization system according to claim 36, wherein at least one of the following is held true (a) said hyperpolarized substance comprises water;

(b) said at least one unhyperpolarized portion comprises body fats;

(c) said at least one hyperpolarized portion comprises body fats;

(c) said specimen is selected from the group consisting of a mammal, a human, a premature neonate, a reptile, a sea animal, a rodent, a biological specimen, a biological organ, an amphibian, in vivo biological tissue, in vivo biological tissue organ, ex vivo biological tissue, ex vivo biological organ and any combination thereof; and

any combination thereof.

39. A system for imaging at least one unhyperpolarized portion of a specimen comprising:

a fluidly-sealable inner chamber accommodating said specimen;

a fluidly-sealable outer chamber encompassing said fluidly-sealable inner chamber and comprising a hyperpolarized substance, and

an imaging device,

wherein said specimen is fluidly-isolated from said hyperpolarized substance and said hyperpolarized substance hyperpolarizes said at least one unhyperpolarized portion by electromagnetic coupling said hyperpolarized substance and said at least one unhyperpolarized portion such that said imaging device is enabled to detect the presence of said at least one hyperpolarized portion.

40. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 39, wherein said electromagnetic coupling is generated by an RF signal generating system located in proximity to said imaging device and RF signal generating system comprises an RF signal generator and an RF antenna.

41. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 40, wherein said RF signal generating system is adapted to excite nuclei of said hyperpolarized substance such that RF radiation emitted by de-excitation of said excited nuclei hyperpolarizes said at least one unhyperpolarized portion.

42. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 41, wherein said electromagnetic radiation comprises RF radiation.

43. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 41, said system further comprising at least one RF receiving coil located within said inner chamber and located in proximity to said at least one hyperpolarized portion and adapted to receive RF radiation emitted by said at least one hyperpolarized portion.

44. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 43, said system further comprising a displacement system adapted to displace said at least one RF receiving coil to said proximity location and said displacement of said at least one RF receiving coil is selected from the group consisting of a translational displacement parallel to a longitudinal axis of said inner chamber and with an accuracy of at least 3 mm to said at least one hyperpolarized portion and a rotational displacement about said longitudinal axis of said inner chamber and any combination thereof.

45. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 39, wherein said imaging system detects and analyzes said radiation emitted by said at least one hyperpolarized portion and said imaging system is adapted to generate a plurality of images of said at least one hyperpolarized portion of said specimen.

46. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 39, wherein said imaging device is selected from the group consisting of an MRI device, an NMR device, an MRI device, a CT device, an X-ray device, an ultrasound device, a fluorescence device, a thermographic device and any combination thereof.

47. The system for imaging at least one unhyperpolarized portion of a specimen according to claim 39, wherein said specimen is selected from the group consisting of a mammal, a human, a premature neonate, a reptile, a sea animal, a rodent, a biological specimen, a biological organ, an amphibian, in vivo biological tissue, in vivo biological tissue organ, ex vivo biological tissue, ex vivo biological organ and any combination thereof.

48. A method for imaging at least one unhyperpolarized portion of a specimen comprising:

providing an imaging device for generating a plurality of images of at least one hyperpolarized portion of said specimen;

locating an indirect-hyperpolarization device within said imaging device, said indirect-hyperpolarization device comprises;

a fluidly-sealable outer chamber;

a fluidly-sealable inner chamber encompassed by said fluidly-sealable outer chamber and accommodating said specimen wherein said specimen is fluidly-isolated from said hyperpolarized substance, and

hyperpolarizing said at least one unhyperpolarized portion;

generating a plurality of images of said at least one hyperpolarized portion.

49. The method for imaging at least one unhyperpolarized portion of a specimen comprising according to claim 48, further comprising locating and aligning said inner chamber within said outer chamber.

50. The method for imaging at least one unhyperpolarized portion of a specimen comprising according to claim 49, further comprising locating an RF signal generating system for generating and transmitting RF energy thereby exciting the nuclei of said hyperpolarized substance and wherein de-excitation of said nuclei hyperpolarizes said at least one unhyperpolarized portion.

51. The method for imaging at least one unhyperpolarized portion of a specimen comprising according to claim 50, further comprising locating an RF receiving transmitting coil in proximity to said at least one hyperpolarized portion for detecting RF radiation emitted by said at least one hyperpolarized portion.