AUTOMATED SYNCHRONIZED NAVIGATION SYSTEM FOR DIGITAL PATHOLOGY IMAGING
First Claim
1. A computer-implemented method for synchronizing navigation in pathology stain images, the method comprising the steps performed by one or more computers of:
- (a) downscaling the pathology stain images;
(b) estimating rotation of the downscaled images;
(c) aligning the downscaled images to generate aligned coordinates; and
(d) transforming the aligned coordinates to original image coordinates in the pathology stain images to thereby generate alignment data.
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Abstract
A method for synchronizing navigation in pathology stain images includes (a) downscaling the pathology stain images, (b) estimating rotation of the downscaled images, (c) aligning the downscaled images to generate aligned coordinates, and (d) transforming the aligned coordinates to original image coordinates in the pathology stain images to thereby generate alignment data. Also provided is a system for synchronized navigation in pathology stain images having original resolutions comprising a downscaler, a rotation estimator, an alignment module, and a coordinate transformer. The system may also include an image display system to display corresponding areas of the pathology stain images.
26 Citations
20 Claims
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1. A computer-implemented method for synchronizing navigation in pathology stain images, the method comprising the steps performed by one or more computers of:
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(a) downscaling the pathology stain images; (b) estimating rotation of the downscaled images; (c) aligning the downscaled images to generate aligned coordinates; and (d) transforming the aligned coordinates to original image coordinates in the pathology stain images to thereby generate alignment data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A computer-implemented system for synchronized navigation in pathology stain images, comprising:
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a downscaler to detect tissue areas and downsample the pathology stain images; a rotation estimator to determine a rotation angle and rotate the downscaled images; an alignment module to align the downscaled images to generate aligned coordinates; and a coordinate transformer to transform the aligned coordinates to original image coordinates in the pathology stain images to thereby generate alignment data. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification