METHODS FOR PREDICTING AND TREATING INFECTION-INDUCED ILLNESSES AND PREDICTING THE SEVERITY OF INFECTION-INDUCED ILLNESSES
First Claim
1. A method for diagnosing or determining the likelihood that a subject will develop one or more infection-induced illness(es) comprising the steps of:
- a) measuring the amount of bacterial nucleic acid or peptide in at least one sample from said subject;
b) measuring the amount of a mitochondrial nucleic acid or peptide in said at least one sample or in a second sample from said subject; and
c) comparing the amount of bacterial nucleic acid or peptide measured in step (a) with the amount of mitochondrial nucleic acid or peptide measured in step (b),wherein an increased ratio of the amount of mitochondrial nucleic acid or peptide to the amount of bacterial nucleic acid or peptide indicates the subject has an increased likelihood of later developing one or more infection-induced illness(es), the subject has one or more infection-induced illness(es), or the subject is likely to develop one or more severe infection-induced illness(es) in the future.
3 Assignments
0 Petitions
Accused Products
Abstract
The invention provides methods for determining the propensity to develop, or the presence of, one or more infection-induced illness(es). The invention further provides methods of treating an infection (e.g., bacterial infection), methods of diagnosing an infection-induced illness in a subject, and methods of predicting the future severity of one or more infection-induced illness(es). Also provided are kits for determining the likelihood or propensity of a subject to develop one or more infection-induced illness(es) and kits for diagnosing one or more infection-induced illness(es) in a subject and identifying a subject as having an increased risk of later developing one or more severe infection-induced illness(es).
50 Citations
89 Claims
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1. A method for diagnosing or determining the likelihood that a subject will develop one or more infection-induced illness(es) comprising the steps of:
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a) measuring the amount of bacterial nucleic acid or peptide in at least one sample from said subject; b) measuring the amount of a mitochondrial nucleic acid or peptide in said at least one sample or in a second sample from said subject; and c) comparing the amount of bacterial nucleic acid or peptide measured in step (a) with the amount of mitochondrial nucleic acid or peptide measured in step (b), wherein an increased ratio of the amount of mitochondrial nucleic acid or peptide to the amount of bacterial nucleic acid or peptide indicates the subject has an increased likelihood of later developing one or more infection-induced illness(es), the subject has one or more infection-induced illness(es), or the subject is likely to develop one or more severe infection-induced illness(es) in the future. - View Dependent Claims (2, 4, 5, 6, 7, 8, 10, 11, 16, 17, 54, 55, 56, 57, 58, 59, 88, 89)
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3. (canceled)
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9. (canceled)
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12-15. -15. (canceled)
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18-53. -53. (canceled)
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60-74. -74. (canceled)
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75. A kit for diagnosing or determining the likelihood that a subject will develop one or more infection-induced illness(es) comprising:
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a) one or more first oligonucleotide primers effective for the amplification of a bacterial nucleic acid or one or more antibodies that specifically bind to one or more bacterial peptides; b) one or more second oligonucleotide primers effective for the amplification of a mitochondrial nucleic acid or one or more antibodies that specifically bind to one or more mitochondrial peptides; and c) instructions for using said first and second oligonucleotide primers or said antibodies for determining the likelihood the subject will develop one or more infection-induced illness(es), for diagnosing the subject as having one or more infection-induced illness(es), or for predicting the future severity of one or more infection-induced illness(es) in the subject.
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76-87. -87. (canceled)
Specification