NANOPARTICLES COATED WITH AMPHIPHILIC BLOCK COPOLYMERS
First Claim
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1. A method of producing stable amphiphilic block copolymer coated single dispersed nanoparticles comprising:
- a) mixing a solution of amphiphilic block copolymer with a colloidal suspension of nanoparticles to generate a mixture, wherein said amphiphilic block copolymer comprises at least one functional group having an affinity for said nanoparticles;
b) treating said mixture at a temperature of above about 60 degrees Celsius to generate a treated mixture; and
c) adding at least a portion of said treated mixture to deionized water such that a solution is generated that comprises amphiphilic block copolymer single dispersed nanoparticles.
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Abstract
The present provides amphiphilic block copolymer coated surfaces (e.g., nanoparticles, medical devices, etc.) and methods of preparing such surfaces. In certain embodiments, the present invention provides amphiphilic block copolymer coated single dispersed nanoparticles, which are stable in buffer (e.g., PBS) and have neutral but functionable surfaces, and methods of preparing the same.
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23 Claims
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1. A method of producing stable amphiphilic block copolymer coated single dispersed nanoparticles comprising:
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a) mixing a solution of amphiphilic block copolymer with a colloidal suspension of nanoparticles to generate a mixture, wherein said amphiphilic block copolymer comprises at least one functional group having an affinity for said nanoparticles; b) treating said mixture at a temperature of above about 60 degrees Celsius to generate a treated mixture; and c) adding at least a portion of said treated mixture to deionized water such that a solution is generated that comprises amphiphilic block copolymer single dispersed nanoparticles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. Amphiphilic block copolymer coated single dispersed nanoparticles which are stable in buffer solution comprising:
- a population of single nanoparticles encapsulated in a shell formed by said amphiphilic block copolymers, said amphiphilic block copolymers contains at least one functional group having an affinity for the surface of said nanoparticles in its hydrophobic part and wherein said amphiphilic block copolymers coated nanoparticles have electrically neutralized surfaces and provide capability for further functionalization via thiol-disulfide exchange reactions.
- View Dependent Claims (18, 19, 20, 21, 22, 23)
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