FUNCTIONAL LIGANDS TO TARGET MOLECULES

• US 20130245243A1
• Filed: 01/23/2013
• Published: 09/19/2013
• Est. Priority Date: 06/06/2008
• Status: Active Grant

• Current Assignee: Base Pair Biotechnologies, Inc.
• Original Assignee: Base Pair Biotechnologies, Inc.
• Inventors: Jackson, George W.
• Granted Patent: US 9,035,034 B2
• Time in Patent Office: Days
• US Class Current: 536/23.1
• CPC Class Codes: C12N 15/115 Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
• CPC Class Codes: C12N 2310/16 Aptamers
• CPC Class Codes: C12N 2320/11 for the determination of target sites, i.e. of active nucleic acids
• CPC Class Codes: C12N 2330/31 Libraries, arrays

Abstract

The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.

Claims

1. A ligand to a target molecule comprising a nucleic acid sequence having substantial homology or identity to a sequence selected from the group consisting of sequence IDs Seq40, Seq41, Seq42, Seq43, Seq44, Seq45, Seq46, Seq47, Seq48, and Seq49.

2. A ligand to a target molecule comprising a modified nucleic acid sequence having substantial homology or identity to a sequence selected from the group consisting of sequence IDs Seq40, Seq41, Seq42, Seq43, Seq44, Seq45, Seq46, Seq47, Seq48, and Seq49.