Pulmonary Arterial Hemodynamic Monitoring for Chronic Obstructive Pulmonary Disease Assessment and Treatment
First Claim
1. A method of predicting the progression or improvement of chronic obstructive pulmonary disease (COPD) in a subject, or predicting an outcome in a subject having COPD, comprisinga. obtaining a pulmonary arterial (PA) hemodynamic reading from the subject, wherein the PA hemodynamic reading comprises a PA hemodynamic waveform;
- b. processing the PA hemodynamic waveform to obtain a PA hemodynamic parameter; and
c. comparing the PA hemodynamic parameter obtained from the subject to a standard;
wherein an increase or decrease in the PA hemodynamic parameter as compared to the standard indicates the progression of COPD, the improvement of COPD, the outcome of COPD, or a combination thereof.
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Abstract
Provided herein are methods for assessing, treating, and for developing new treatments for COPD. Methods can involve obtaining one or more PA hemodynamic readings from a subject with COPD, processing the PA hemodynamic readings to obtain one or more PA hemodynamic parameters, and using the one or more PA hemodynamic parameters to assess, treat, and/or develop new treatments for COPD. The methods can optionally be used to evaluate the progress of (COPD) in a subject, or to predict an outcome in a subject having COPD.
27 Citations
23 Claims
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1. A method of predicting the progression or improvement of chronic obstructive pulmonary disease (COPD) in a subject, or predicting an outcome in a subject having COPD, comprising
a. obtaining a pulmonary arterial (PA) hemodynamic reading from the subject, wherein the PA hemodynamic reading comprises a PA hemodynamic waveform; -
b. processing the PA hemodynamic waveform to obtain a PA hemodynamic parameter; and c. comparing the PA hemodynamic parameter obtained from the subject to a standard; wherein an increase or decrease in the PA hemodynamic parameter as compared to the standard indicates the progression of COPD, the improvement of COPD, the outcome of COPD, or a combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of evaluating the progression of heart failure (HF) in a subject comprising obtaining a pulmonary arterial (PA) hemodynamic reading from the subject using an implantable pressure sensor, and comparing the PA hemodynamic reading to a standard,
wherein the PA hemodynamic reading is taken while the subject is exercising, and wherein an increase or decrease in the PA hemodynamic reading as compared to the standard indicates the progression of HF, the improvement of HF, the outcome of HF, or a combination thereof.
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14. An ambulatory unit for measuring a physical parameter detected by a wireless sensor, the system comprising:
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an antenna providing electromagnetic coupling to the wireless sensor, wherein a signal the physical parameter is received through the antenna; a processing unit and a memory operably coupled to the processing unit, the memory having computer executable instructions stored thereon that, when executed by the processing unit, cause the processing unit to; cycle between a communication mode and a low power mode; and communicate the signal to a remote base unit over a communication link during the communication mode. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification