DRUG DELIVERY DEVICE HAVING A SPRING ELEMENT

• US 20130245565A1
• Filed: 11/28/2011
• Published: 09/19/2013
• Est. Priority Date: 11/29/2010
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Leak, David Martin, Boyd, Malcolm Stanley, De Sausmarez Lintell, Daniel Thomas, Bilton, Simon Lewis, Higgins, Daniel David
• Granted Patent: US 9,402,961 B2
• Time in Patent Office: Days
• US Class Current: 604/246
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 2005/202 cocking means, e.g. to bias the main drive spring of an injector
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31548 Mechanically operated dose setting member
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

A drug delivery device having a spring element that provides dispense assistance. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, and a mechanical coupling having a spring element. The variable dose setting mechanism is operably coupled to a first reservoir holding a first medicament, and the variable dose setting mechanism comprises a dose setter. The fixed dose setting mechanism is operably coupled to a second reservoir holding a second medicament. The mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter, and the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during variable dose setting. Still further, the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to assist with dispense of the fixed dose.

Claims

1-14. -14. (canceled)

15. A drug delivery device comprising:

a variable dose setting mechanism operably coupled to a first reservoir holding a first medicament, the variable dose setting mechanism having a dose setter;

a fixed dose setting mechanism operably coupled to a second reservoir holding a second medicament;

a mechanical coupling, wherein the mechanical coupling operably couples the variable dose setting mechanism and the fixed dose setting mechanism and wherein the mechanical coupling comprises a spring element;

wherein the variable dose setting mechanism is configured to set a variable dose of the first medicament upon activation of the dose setter,

wherein the fixed dose setting mechanism is configured to set a fixed dose of the second medicament during dose setting, and

wherein the spring element is configured to store energy during dose setting and to transfer stored energy to the fixed dose setting mechanism to at least assist with dispense of the fixed dose.

16. The drug delivery device of claim 15, wherein the variable dose setting mechanism is a rotationally-set variable dose setting mechanism, and wherein the fixed dose setting mechanism is an axially-set fixed dose setting mechanism.

17. The drug delivery device of claim 15, wherein the mechanical coupling further comprises:

a lift cylinder, wherein the lift cylinder comprises (i) the spring element, (ii) a compression cylinder, (iii) an internal groove, and (iv) a lifting surface, and (v) a lift pin;

a lifting collar;

an engagement pin, wherein the engagement pin is engageable with the lifting collar;

wherein (i) the lifting collar is configured to lift the lift cylinder during dose setting due to engagement with the engagement pin, (ii) the lifting surface is configured to contact the lift pin and force the lift pin through the internal groove, thereby forcing the compression cylinder to be lifted in a proximal direction, and (iii) the spring element is configured to be compressed due to the lifting of the compression cylinder in the proximal direction.

18. The drug delivery device of claim 17, wherein the groove is an L-shaped groove.

19. The drug delivery device of claim 15, wherein the dose setter comprises a drive feature, wherein the fixed dose setting mechanism further comprises a reciprocating element, and wherein the mechanical coupling further comprises:

a cam having a groove;

an engagement feature that is engageable with the groove,

wherein (i) the drive feature of the dose setter is configured to force the cam to rotate during dose setting, (ii) the engagement feature is configured to follow the groove and move in a proximal direction, (iii) the reciprocating element is configured to be lifted due to the movement of the engagement feature in the proximal direction, and (iv) the spring element is configured to be compressed due to the lifting of the reciprocating element.

20. The drug delivery device of claim 15, wherein the fixed dose setting mechanism further comprises a reciprocating element, wherein the mechanical coupling further comprises:

a lifting collar having an internal helical groove, wherein the lifting collar is restrained in rotation relative to the fixed dose mechanism but is axially moveable; and

an engagement feature;

wherein (i) the dose setter is configured to follow a helical path during dose setting, (ii) the engagement feature is configured to follow the helical path and contact an underside of the lifting collar to lift the reciprocating element of the fixed dose setting mechanism, and (iv) wherein the spring element is configured to be compressed due to the lifting of the reciprocating element.

21. The drug delivery device of claim 20, wherein the engagement feature is configured to enter the internal helical groove at a helix entry point after the fixed dose is set.

22. The drug delivery device of claim 15, wherein the fixed dose setting mechanism further comprises a reciprocating element, wherein the mechanical coupling further comprises:

an internal clutch mechanism;

a lifting collar;

a lifting groove;

an engagement feature capable of engagement with the lifting groove,

wherein the dose setter is configured to initially move axially during dose setting such that the variable dose setting mechanism lifts the reciprocating element, wherein the spring element is configured to be compressed by the lifting of the reciprocating element,

wherein the internal clutch mechanism is configured to allow the dose setter to rotate to set the variable dose after the fixed dose is set.

23. The drug delivery device of claim 15, wherein the mechanical coupling further comprises:

a lifting collar having at least one clip feature;

an engagement feature;

at least one restraining feature disposed on a device body;

wherein (i) the engagement feature is configured to contact an underside of the lifting collar during dose setting and lift the lifting collar to a set point, (ii) the spring element is configured to be compressed due to the lifting of the lifting collar to the set point, (iii) the at least one clip feature is configured to engage with the at least one restraining feature on the device body at the set point to keep the spring element in a compressed state.

24. The drug delivery device of claim 15, wherein the mechanical coupling further comprises:

a cam having a groove;

a cam follower,

wherein, during dose setting, (i) the cam is configured to force the cam follower to be lifted as the cam follower follows the groove, and (ii) the spring element is configured to be compressed due to the lifting of the cam follower.

25. The drug delivery device of claim 15, wherein the fixed dose setting mechanism further comprises a reciprocating element, wherein the mechanical coupling further comprises:

a drive collar;

a cam,

wherein (i) the drive collar is configured to rotate the cam during dose setting, (ii) the cam is configured to lift the reciprocating element of the fixed dose setting mechanism, and (iii) the spring element is configured to be compressed due to the lifting of the reciprocating element.

26. The drug delivery device of claim 25, wherein a pin of the fixed dose setting mechanism is configured to follow a groove of the cam during dose setting to lift the reciprocating element of the fixed dose mechanism.

27. The drug delivery device of claim 15, wherein the mechanical coupling further comprises:

a drive collar; and

a winding collar comprising (i) the spring element, wherein the spring element is a torsion spring, wherein the torsion spring comprises a spring arm and (ii) a spring retainer having a groove, wherein the groove comprises an escapement,

wherein (i) the drive collar is configured to force the winding collar to rotate during dose setting, and (ii) the winding collar is configured to force the spring arm to follow the groove until the spring arm is forced into the escapement such that torsional spring energy is stored.

28. The drug delivery device of claim 27, wherein during dispense, (i) rotation of the winding collar forces the spring arm out of the escapement, and (ii) the torsional spring energy of the torsion spring forces the winding collar to rotate, thereby forcing a ratchet of the fixed dose setting mechanism to rotate and assist advancement of a spindle of the fixed dose setting mechanism.